AUTHOR=Wu Yafei , Zhang Jigang , Zhang Xue , Zhou Heming , Liu Gaolin , Li Qin 

TITLE=Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00198

DOI=10.3389/fphar.2020.00198

ISSN=1663-9812

ABSTRACT=<p>Cancer stem cells (CSCs) are subpopulations of cells with stem cell characteristics that produce both cancerous and non-tumorigenic cells in tumor tissues. The literature reports that CSCs are closely related to the development of hepatocellular carcinoma (HCC) and promote the malignant features of HCC such as high invasion, drug resistance, easy recurrence, easy metastasis, and poor prognosis. This review discusses the origin, molecular, and biological features, functions, and applications of CSCs in HCC in recent years; the goal is to clarify the importance of CSCs in treatment and explore their potential value in HCC-targeted therapy.</p>