AUTHOR=Li Meng , Wang Tianlong , Xiao Wei , Zhao Lei , Yao Dongxu 

TITLE=Low-Dose Dexmedetomidine Accelerates Gastrointestinal Function Recovery in Patients Undergoing Lumbar Spinal Fusion

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01509

DOI=10.3389/fphar.2019.01509

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> Dexmedetomidine possesses sedative, sympatholytic, and opioid-sparing properties, but its impact on postoperative gastrointestinal function is controversial.</p><p><bold>Methods:</bold> This single-center, prospective, randomized study compared low-dose dexmedetomidine and placebo on gastrointestinal function recovery and inflammation after posterior lumbar spinal fusion. Sixty-six patients were randomized into two groups and received normal saline (control group) or dexmedetomidine (DEX group) during posterior lumbar fusion. Blood was taken at five timepoints to measure lipopolysaccharides, tumor necrosis factor-α, and C-reactive protein. The primary outcome was duration to first flatus. The secondary outcomes were inflammatory mediators and determination of correlations between perioperative factors and duration to first flatus.</p><p><bold>Results:</bold> Patients in DEX group showed significantly lower duration to first flatus (15.37 [13.35–17.38] vs 19.58 [17.31–21.86] h; <italic>p</italic> = 0.006) and overall sufentanil consumption (67.19 [63.78–70.62] vs 74.67 [69.96–79.30] μg; <italic>p</italic> = 0.011) than controls. Lipopolysaccharides, tumor necrosis factor-α, and C-reactive protein did not differ between the groups at any timepoint (all <italic>p &gt;</italic> 0.05). Multiple linear regression modeling assessed the ability of independent variables to predict variance in duration to first flatus (adjusted <italic>R<sup>2</sup></italic> = 0.379, <italic>p</italic> = 0.000). In the model, age (<italic>β</italic> = 0.243, <italic>p</italic> = 0.003), gender (<italic>β</italic> = −3.718, <italic>p</italic> = 0.011), BMI (<italic>β</italic> = −0.913, <italic>p</italic> = 0.001), operative segments (<italic>β</italic> = −4.079, <italic>p</italic> = 0.028), and overall sufentanil consumption (<italic>β</italic> = 0.426, <italic>p</italic> = 0.000) contributed significantly.</p><p><bold>Conclusions:</bold> Thus, low-dose dexmedetomidine accelerates gastrointestinal function recovery after lumbar spinal fusion. The effect may be partially produced by opioid-sparing effects rather than inhibition of inflammation.</p><p><bold>Clinical Trial Registration:</bold><ext-link ext-link-type="uri" xlink:href="www.chictr.org.cn, identifier ChiCTR1800018127" xmlns:xlink="http://www.w3.org/1999/xlink">www.chictr.org.cn, identifier ChiCTR1800018127</ext-link>.</p>