AUTHOR=Zhang Chaohe , Sheng Jiyao , Li Guangquan , Zhao Lihong , Wang Yicun , Yang Wei , Yao Xiaoxiao , Sun Lihuan , Zhang Zhuo , Cui Ranji 

TITLE=Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01461

DOI=10.3389/fphar.2019.01461

ISSN=1663-9812

ABSTRACT=<p>Numerous studies have shown that berberine and its derivatives demonstrate important anti-tumor effects. However, the specific underlying mechanism remains unclear. Therefore, based on systems pharmacology, this review summarizes the information available on the anti-tumor effects and mechanism of berberine and its derivatives. The action and potential mechanism of action of berberine and its derivatives when used in the treatment of complex cancers are systematically examined at the molecular, cellular, and organismic levels. It is concluded that, with further in-depth investigations on their toxicity and efficacy, berberine and its derivatives have the potential for use as drugs in cancer therapy, offering improved clinical efficacy and safety.</p>