AUTHOR=Taus Francesco , Meneguzzi Alessandra , Castelli Marco , Minuz Pietro TITLE=Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence? JOURNAL=Frontiers in Pharmacology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01256 DOI=10.3389/fphar.2019.01256 ISSN=1663-9812 ABSTRACT=

Platelet-derived large extracellular vesicles (often referred to as microparticles in the field of cardiovascular disease) have been identified as effector in the atherothrombotic process, therefore representing a target of pharmacological intervention of potential interest. Despite that, limited evidence is so far available concerning the effects of antiplatelet agents on the release of platelet-derived extracellular vesicles. In the present narrative review, the mechanisms leading to vesiculation in platelets and the pathophysiological processes implicated will be discussed. This will be followed by a summary of the present evidence concerning the effects of antiplatelet agents under experimental conditions and in clinical settings.