AUTHOR=Ru Yi , Luo Ying , Zhou Yaqiong , Kuai Le , Sun Xiaoying , Xing Meng , Liu Liu , Lu Yi , Hong Seokgyeong , Chen Xi , Song Jiankun , Luo Yue , Fei Xiaoya , Li Bin , Li Xin 

TITLE=Adverse Events Associated With Treatment of Tripterygium wilfordii Hook F: A Quantitative Evidence Synthesis

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01250

DOI=10.3389/fphar.2019.01250

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold><italic>Tripterygium wilfordii</italic> Hook F can cause adverse effects (AEs) in clinical application and may be harmful to human health. This study aim to summarize the AEs caused by <italic>T. wilfordii</italic> tgpolyglycoside (TWP), the most common preparation of <italic>T. wilfordii</italic> Hook F for clinical use.</p><p><bold>Methods:</bold> The Cochrane Library, EMBASE, PubMed, and Web of Science were searched to identify potential articles on this topic. All single-arm trials, controlled clinical trials, and randomized controlled trials were selected and summarized. Meta-regression was used to determine the sources of heterogeneity, and subgroups were used to identify factors leading to AEs.</p><p><bold>Results:</bold> Forty-six studies, comprising 25 randomized controlled trials, 13 controlled clinical trials, and 8 single-arm trials, were included in this meta-analysis, representing 2437 enrolled TWP-treated participants. Combined intervention, drug dosage, medication treatment, pharmaceutical manufacturers, and specific organ toxicity were identified as potential factors leading to TWP-induced AEs in this meta-analysis. In patients treated with TWP, the global incidence of AEs was 30.75% (95% confidence interval [21.18–40.33], <italic>I</italic><sup>2</sup> = 97%), and that of severe grade AEs was 4.68% (95% confidence interval [0.00–12.72], <italic>I</italic><sup>2</sup> = 53%). Organ-specific analyses indicated that TWP treatment elicited intestinal toxicity, reproductive toxicity, hepatotoxicity, nephrotoxicity, hematotoxicity, cutaneous toxicity, and other damages. The AEs analyzed in the subgroups of combined intervention, drug dosage, medication treatment, and pharmaceutical manufacturers were considered as primary outcomes, and organic-specific AEs were considered as secondary outcomes.</p><p><bold>Conclusions:</bold> The occurrence of TWP-induced AEs was systemic, organ-specific, and related to medication course, combined intervention, and drug dosage.</p>