AUTHOR=Khan Farzana , Sarker Md. Moklesur Rahman , Ming Long Chiau , Mohamed Isa Naina , Zhao Chao , Sheikh Bassem Y. , Tsong Hiew Fei , Rashid Mohammad A. 

TITLE=Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01223

DOI=10.3389/fphar.2019.01223

ISSN=1663-9812

ABSTRACT=<p><italic>Gymnema sylvestre</italic> is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. This plant is widely used as a traditional therapy for different purposes. Even now it is being used as a dietary supplement due to its numerous therapeutic uses. It is known to have blood glucose lowering potential and, thus, is widely used in traditional and Ayurvedic systems of medicine. It renders glucose lowering activity due to the presence of phytochemicals, such as gurmarin, gymnemic acid as well as gymnemasaponins. Gymnema sylvestre is also known to have anti-oxidant, antibiotic, anti-inflammatory, antiviral, gastro and hepatoprotective, anticancer and lipid-lowering activities. This review discusses in details on different pharmacological and clinical potentials of Gymnema sylvestre and its chemical constituents associated with its therapeutic potentials.</p>