AUTHOR=Xin Ning , Fen Zhou , Li Cheng , Yan Xiao , Runming Jin 

TITLE=Intracranial Hemorrhage Following Oral Low-Dose Methotrexate After Multiple Toxicities Caused by High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01072

DOI=10.3389/fphar.2019.01072

ISSN=1663-9812

ABSTRACT=<p>An 11-year-old male patient with the deletion of <italic>IKZF1</italic> (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(<italic>BCR-ABL1</italic>) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate. The patient recovered completely after therapy. However, intracranial hemorrhage (ICH) occurred following oral methotrexate at a dose of 25 mg/m<sup>2</sup> in maintenance treatment, and he had neurological sequelae including hemiplegic paralysis.</p>