AUTHOR=Li Jun-yi , Sun Fei , Zhou Hai-feng , Yang Jia , Huang Cong , Fan Heng 

TITLE=A Systematic Review Exploring the Anticancer Activity and Mechanisms of Glucomannan

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00930

DOI=10.3389/fphar.2019.00930

ISSN=1663-9812

ABSTRACT=<p>Glucomannan, long recognized as the active ingredient of the traditional Chinese medicinal herb Konjac glucomannan, is a naturally occurring polysaccharide existing in certain plant species and fungi. Due to its special property to also serve as a dietary supplement, glucomannan has been widely applied in clinic to lower body weight and circulation cholesterol level and to treat constipation, diabetes, and arterial sclerosis. Besides the regulatory role engaged with gastroenterological and metabolic syndrome, recently, its therapeutic effect and the underlying mechanisms in treating cancerous diseases have been appreciated by mounting researches. The present review aims to emphasize the multifaceted aspects of how glucomannan exerts its anti-tumor function.</p>