AUTHOR=Yu Guohua , Luo Zhiqiang , Wang Wubin , Li Yihao , Zhou Yating , Shi Yuanyuan 

TITLE=Rubus chingii Hu: A Review of the Phytochemistry and Pharmacology

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00799

DOI=10.3389/fphar.2019.00799

ISSN=1663-9812

ABSTRACT=<p><italic>Rubus chingii</italic> Hu (<italic>R. chingii</italic>), referred to as “Fu-Pen-Zi” in Chinese, has great medicinal and dietary values since ancient times. The dried fruits of <italic>R. chingii</italic> have been widely used in traditional Chinese medicine (TCM) for the treatment of kidney enuresis and urinary frequency for centuries. According to current findings, <italic>R. chingii</italic> has been reported to contain a variety of chemical constituents, mostly triterpenoids, diterpenoids, flavonoids, and organic acids. These compounds have been demonstrated to be the major bioactive components responsible for pharmacological effects such as anticomplementary, anticancer, antioxidant, antimicrobial, and anti-inflammatory functions. Therefore, this review focused on the up-to-date published data of the literature about <italic>R. chingii</italic> and comprehensively summarized its phytochemistry, pharmacology, quality control, and toxicity to provide a beneficial support to its further investigations and applications in medicines and foods.</p>