AUTHOR=Giannopoulou Efstathia , Katsila Theodora , Mitropoulou Christina , Tsermpini Evangelia-Eirini , Patrinos George P. 

TITLE=Integrating Next-Generation Sequencing in the Clinical Pharmacogenomics Workflow

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00384

DOI=10.3389/fphar.2019.00384

ISSN=1663-9812

ABSTRACT=<p>Pharmacogenomics has been recognized as a fundamental tool in the era of personalized medicine with up to 266 drug labels, approved by major regulatory bodies, currently containing pharmacogenomics information. Next-generation sequencing analysis assumes a critical role in personalized medicine, providing a comprehensive profile of an individual’s variome, particularly that of clinical relevance, comprising of pathogenic variants and pharmacogenomic biomarkers. Here, we propose a strategy to integrate next-generation sequencing into the current clinical pharmacogenomics workflow from deep resequencing to pharmacogenomics consultation, according to the existing guidelines and recommendations.</p>