AUTHOR=Pantziarka Pan , Ghibelli Lina , Reichle Albrecht 

TITLE=A Computational Model of Tumor Growth and Anakoinosis

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00287

DOI=10.3389/fphar.2019.00287

ISSN=1663-9812

ABSTRACT=<p>Anakoinosis is a new cancer treatment paradigm that posits a key role for communicative reprogramming within tumor systems. To date no mathematical or computational models of anakoinosis have been developed. Here we outline the NEATG_A system, a first computational model of communicative reprogramming. The model recapitulates key features of real tumor systems and responses to both traditional cytotoxic treatments and biomodulatory/anakoinotic treatments. Results are presented and discussed, particularly with respect to the implications for future cancer treatment protocols.</p>