AUTHOR=Xiao Xiao , Wang Ting , Li Leijiao , Zhu Zhongli , Zhang Weina , Cui Guihua , Li Wenliang 

TITLE=Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00110

DOI=10.3389/fphar.2019.00110

ISSN=1663-9812

ABSTRACT=<p>A strategy for preparing composite micelles (CM) containing both cisplatin(IV) [CisPt(IV)] prodrug and capecitabine using a co-assembly method is described in this study. The CM are capable of an effective release of the anticancer drug cisplatin(II) [CisPt(II)] and capecitabine via acid hydrolysis once they are internalized by cancer cells. Moreover, the CM display a synergistic effect <italic>in vitro</italic> and the combination therapy in the micellar dosage form leads to reduced systemic toxicity and enhanced antitumor efficacy <italic>in vivo</italic>.</p>