AUTHOR=Dong Hang , Jiang Siyi , Fu Yunfeng , Luo Yanwei , Gui Rong , Liu Jing 

TITLE=Upregulation of lncRNA NR_046683 Serves as a Prognostic Biomarker and Potential Drug Target for Multiple Myeloma

JOURNAL=Frontiers in Pharmacology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00045

DOI=10.3389/fphar.2019.00045

ISSN=1663-9812

ABSTRACT=<p><bold>Aim:</bold> To investigate the prognostic value of lncRNA NR_046683 in multiple myeloma (MM).</p><p><bold>Methods:</bold> High-throughput lncRNA array was combined with bioinformatics techniques to screen differentially expressed lncRNA in MM. qRT-PCR was adopted to determine the expression of target lncRNAs in MM patients and controls.</p><p><bold>Results:</bold> It was found for the first time that lncRNA NR_046683 is closely related to the prognosis of MM. It was also detected in tumor cell lines KM3, U266, especially in drug-resistant cell lines KM3/BTZ and MM1R. The NR_046683 expression differed significantly in patients of different MM subtypes and staging. Moreover, the overexpression of NR-046683 is closely related to β<sub>2</sub>-microglobulin. We also found that the overexpression of NR-046683 correlates to chromosomal aberrations, such as del(13q14), gain 1q21, and t(4;14).</p><p><bold>Conclusion:</bold> lncRNA NR_046683 can serve as a novel biomarker for potential drug target and prognostic prediction in MM.</p>