AUTHOR=Zhang Lei , Ding Zhimin , Dong Fajin , Wu Huaiyu , Liang Weiyu , Tian Hongtian , Ye Xiuqin , Luo Hui , Xu Jinfeng 

TITLE=Diagnostic Performance of Multiple Sound Touch Elastography for Differentiating Benign and Malignant Thyroid Nodules

JOURNAL=Frontiers in Pharmacology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01359

DOI=10.3389/fphar.2018.01359

ISSN=1663-9812

ABSTRACT=<p>This study evaluated the ability of Sound Touch Elastography (STE) to distinguish malignant from benign thyroid nodules by quantifying tumor stiffness using the elastic ratio (EI) and shear modulus (G). Eighty-six patients with 86 nodules were enrolled in this study. There were 24/86 (27.90%) thyroid papillary carcinomas (TPC) and 62/86 (72.10%) benign nodules. The mean EI was significantly lower in TPCs than in benign nodules. The EI area under the receiver operating characteristic curve (ROC) was 80%. The EI cutoff value for TPCs was 0.215%. The sensitivity (Sen), specificity (Spe), positive likelihood ratio (LR+), and negative likelihood ratio (LR-) were 71%, 73%, 2.58, and 0.40, respectively. <italic>G</italic><sub>max</sub>, <italic>G</italic><sub>mean</sub>, and <italic>G</italic><sub>sd</sub> were significantly higher in TPCs than in benign nodules. There were no significant differences in <italic>G</italic><sub>min</sub>. Compared with other G parameters, <italic>G</italic><sub>max</sub> with an optimal cutoff value of 15.82 kPa had the highest AUROC value (84%). The Sen, Spe, LR+, and LR- were 79.17%, 79.03%, 3.776, and 0.261, respectively. We pooled the EI, <italic>G</italic><sub>max</sub>, <italic>G</italic><sub>mean</sub>, and <italic>G</italic><sub>sd</sub> and the pooled-Sen, Spe, LR+, LR-, diagnostic odds ratio and odds ratio, and area under the summary ROC were 79%, 71%, 2.73, 0.29, 2.23, 9.29, and 82%, respectively. STE could be a new ultrasound diagnostic method for evaluating benign and malignant thyroid nodules.</p>