AUTHOR=Grimaldi Marina , Boulahtouf Abdelhay , Prévostel Corinne , Thierry Alain , Balaguer Patrick , Blache Philippe 

TITLE=A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway

JOURNAL=Frontiers in Pharmacology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01160

DOI=10.3389/fphar.2018.01160

ISSN=1663-9812

ABSTRACT=<p>A constitutive activation of the Wnt/β-catenin pathway is an initiating event in colon carcinogenesis. We developed colon cancer cells models that highlight the non-selectivity of previously described inhibitors of the Wnt pathway and we propose our model as a suitable screening system for inhibitors of the pathway.</p>