AUTHOR=Stradiot Leslie , Mannaerts Inge , van Grunsven Leo A. 

TITLE=P311, Friend, or Foe of Tissue Fibrosis?

JOURNAL=Frontiers in Pharmacology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01151

DOI=10.3389/fphar.2018.01151

ISSN=1663-9812

ABSTRACT=<p>P311 was first identified by the group of <xref ref-type="bibr" rid="B95">Studler et al. (1993)</xref> in the developing brain. In healthy, but mainly in pathological tissues, P311 is implicated in cell migration and proliferation. Furthermore, evidence in models of tissue fibrosis points to the colocalization with and the stimulation of transforming growth factor β1 by P311. This review provides a comprehensive overview on P311 and discusses its potential as an anti-fibrotic target.</p>