AUTHOR=Ma Chiyuan , Zhou Xiaopeng , Xu Kai , Wang Linyan , Yang Yute , Wang Wei , Liu An , Ran Jisheng , Yan Shigui , Wu Haobo , Wu Lidong TITLE=Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats JOURNAL=Frontiers in Pharmacology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00700 DOI=10.3389/fphar.2018.00700 ISSN=1663-9812 ABSTRACT=
As a chronic disease, osteoarthritis (OA) leads to the degradation of both cartilage and subchondral bone, its development being mediated by proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of specnuezhenide (SPN) in OA and its underlying mechanism were studied