AUTHOR=Ge Liang , You Xinru , Huang Jun , Chen Yuejian , Chen Li , Zhu Ying , Zhang Yuan , Liu Xiqiang , Wu Jun , Hai Qian TITLE=Human Albumin Fragments Nanoparticles as PTX Carrier for Improved Anti-cancer Efficacy JOURNAL=Frontiers in Pharmacology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00582 DOI=10.3389/fphar.2018.00582 ISSN=1663-9812 ABSTRACT=

For enhanced anti-cancer performance, human serum albumin fragments (HSAFs) nanoparticles (NPs) were developed as paclitaxel (PTX) carrier in this paper. Human albumins were broken into fragments via degradation and crosslinked by genipin to form HSAF NPs for better biocompatibility, improved PTX drug loading and sustained drug release. Compared with crosslinked human serum albumin NPs, the HSAF-NPs showed relative smaller particle size, higher drug loading, and improved sustained release. Cellular and animal results both indicated that the PTX encapsulated HSAF-NPs have shown good anti-cancer performance. And the anticancer results confirmed that NPs with fast cellular internalization showed better tumor inhibition. These findings will not only provide a safe and robust drug delivery NP platform for cancer therapy, but also offer fundamental information for the optimal design of albumin based NPs.