AUTHOR=Janciauskiene Sabina , Wrenger Sabine , Immenschuh Stephan , Olejnicka Beata , Greulich Timm , Welte Tobias , Chorostowska-Wynimko Joanna 

TITLE=The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

JOURNAL=Frontiers in Pharmacology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00341

DOI=10.3389/fphar.2018.00341

ISSN=1663-9812

ABSTRACT=<p>Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils.</p>