AUTHOR=Du Shuxu , Huang Yaqian , Jin Hongfang , Wang Tianyou 

TITLE=Protective Mechanism of Hydrogen Sulfide against Chemotherapy-Induced Cardiotoxicity

JOURNAL=Frontiers in Pharmacology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00032

DOI=10.3389/fphar.2018.00032

ISSN=1663-9812

ABSTRACT=<p>Over the past few decades, the number of long term survivors of childhood cancers has been increased exponentially. However, among these survivors, treatment-related toxicity, especially cardiotoxicity, is becoming the essential cause of morbidity and mortality. Thus, preventing the treatment-related adverse effects is important to increase the event free survival during the treatment of cancer in children and adolescents. Accumulating evidence has demonstrated that hydrogen sulfide (H<sub>2</sub>S) exerts a protective role on cardiomyocytes through a variety of mechanisms. Here, we mainly reviewed the cardioprotective role of H<sub>2</sub>S in the chemotherapy, and emphatically discussed the possible mechanisms.</p>