AUTHOR=Bhattacharya Anindya TITLE=Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders JOURNAL=Frontiers in Pharmacology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00030 DOI=10.3389/fphar.2018.00030 ISSN=1663-9812 ABSTRACT=
The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an important pathological role in executing ATP-driven danger signal transduction. Emerging data has generated scientific interest and excitement around targeting the P2X7 ion channel as a potential drug target for CNS disorders. Over the past years, a wealth of data has been published on CNS P2X7 biology, in particular the role of P2X7 in microglial cells, and