AUTHOR=Pavan Barbara , Dalpiaz Alessandro , Marani Luca , Beggiato Sarah , Ferraro Luca , Canistro Donatella , Paolini Moreno , Vivarelli Fabio , Valerii Maria C. , Comparone Antonietta , De Fazio Luigia , Spisni Enzo TITLE=Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes JOURNAL=Frontiers in Pharmacology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00018 DOI=10.3389/fphar.2018.00018 ISSN=1663-9812 ABSTRACT=
Geraniol is a natural monoterpene showing anti-inflammatory, antioxidant, neuroprotective and anticancer effects. No pharmacokinetic and bioavailability data on geraniol are currently available. We therefore performed a systematic study to identify the permeation properties of geraniol across intestinal cells, and its pharmacokinetics and bioavailability after intravenous and oral administration to rats. In addition, we systematically investigated the potential hepatotoxic effects of high doses of geraniol on hepatic phase I, phase II and antioxidant enzymatic activities and undertook a hematochemical analysis on mice. Permeation studies performed via HPLC evidenced geraniol permeability coefficients across an