AUTHOR=Nallathamby Neeranjini , Phan Chia-Wei , Seow Syntyche Ling-Sing , Baskaran Asweni , Lakshmanan Hariprasath , Abd Malek Sri N. , Sabaratnam Vikineswary 

TITLE=A Status Review of the Bioactive Activities of Tiger Milk Mushroom Lignosus rhinocerotis (Cooke) Ryvarden

JOURNAL=Frontiers in Pharmacology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00998

DOI=10.3389/fphar.2017.00998

ISSN=1663-9812

ABSTRACT=<p>Edible and medicinal mushrooms are regularly used in natural medicines and home remedies since antiquity for ailments like fever, inflammation, and respiratory disorders. <italic>Lignosus rhinocerotis</italic> (Cooke) Ryvarden is a polypore found in Malaysia and other regions in South East Asia. It can be located on a spot where a tigress drips milk while feeding, hence the name “tiger's milk mushroom.” The sclerotium of <italic>L. rhinocerotis</italic> is highly sought after by the native communities in Malaysia to stave off hunger, relieve cough and asthma, and provide stamina. The genomic features of <italic>L. rhinocerotis</italic> have been described. The pharmacological and toxicity effects, if any, of <italic>L. rhinocerotis</italic> sclerotium have been scientifically verified in recent years. In this review, the validated investigations including the cognitive function, neuroprotection, immune modulation, anti-asthmatic, anti-coagulation, anti-inflammatory, anti-microbial/ anti-viral, anti-obesity, anti-cancer/ anti-tumor, and antioxidant properties are highlighted. These findings suggest that <italic>L. rhinocerotis</italic> can be considered as an alternative and natural medicine in the management of non-communicable diseases. However, there is a paucity of validation studies including human clinical trials of the mycochemicals of <italic>L. rhinocerotis</italic>.</p>