AUTHOR=Lim Sang Hyun , Legere Elizabeth-Ann , Snider Jamie , Stagljar Igor TITLE=Recent Progress in CFTR Interactome Mapping and Its Importance for Cystic Fibrosis JOURNAL=Frontiers in Pharmacology VOLUME=8 YEAR=2018 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00997 DOI=10.3389/fphar.2017.00997 ISSN=1663-9812 ABSTRACT=

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of phenotypic variance resulting from perturbations of this protein interaction network. Studying the collection of CFTR interacting proteins and the differences between the interactomes of mutant and wild type CFTR provides insight into the molecular machinery of the disease and highlights possible therapeutic targets. This mini review focuses on functional genomics and proteomics approaches used for systematic, high-throughput identification of CFTR-interacting proteins to provide comprehensive insight into CFTR regulation and function.