AUTHOR=Yang Chun-tao , Chen Li , Xu Shi , Day Jacob J. , Li Xiang , Xian Ming 

TITLE=Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders

JOURNAL=Frontiers in Pharmacology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00664

DOI=10.3389/fphar.2017.00664

ISSN=1663-9812

ABSTRACT=<p>As an important endogenous gaseous signaling molecule, hydrogen sulfide (H<sub>2</sub>S) exerts various effects in the body. A variety of pathological changes, such as cancer, glycometabolic disorders, and diabetes, are associated with altered endogenous levels of H<sub>2</sub>S, especially decreased. Therefore, the supplement of H<sub>2</sub>S is of great significance for the treatment of diseases containing the above pathological changes. At present, many efforts have been made to increase the <italic>in vivo</italic> levels of H<sub>2</sub>S by administration of gaseous H<sub>2</sub>S, simple inorganic sulfide salts, sophisticated synthetic slow-releasing controllable H<sub>2</sub>S donors or materials, and using H<sub>2</sub>S stimulating agents. In this article, we reviewed the recent development of H<sub>2</sub>S releasing/stimulating reagents and their potential applications in two common pathological processes including cancer and glycometabolic disorders.</p>