AUTHOR=Banna Giuseppe L. , Torino Francesco , Marletta Francesco , Santagati Maria , Salemi Rossella , Cannarozzo Elisa , Falzone Luca , Ferraù Francesco , Libra Massimo TITLE=Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer JOURNAL=Frontiers in Pharmacology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00603 DOI=10.3389/fphar.2017.00603 ISSN=1663-9812 ABSTRACT=
Cancer is the second leading cause of death in the western world. In the era of precision medicine, a significant number of cancer patients can be cured with several anti-cancer therapeutic regimens. However, therapy failure may be caused by treatment side effects, such as diarrhea, especially occurring in patients with gastrointestinal or pelvic malignancies. In particular, diarrhea is one of the most frequent gastrointestinal toxicity during cancer treatment and it can result from nearly bot chemo- and radio-therapeutic strategies currently used. Diarrhea has a serious impact on patients’ quality of life and treatment dosing and schedule modification due to its severity can negatively influence treatment outcomes. In this context, probiotics may play an interesting role in several human diseases with an inflammatory bowel involvement and, among these,