AUTHOR=Festa Carmen , De Marino Simona , Carino Adriana , Sepe Valentina , Marchianò Silvia , Cipriani Sabrina , Di Leva Francesco S. , Limongelli Vittorio , Monti Maria C. , Capolupo Angela , Distrutti Eleonora , Fiorucci Stefano , Zampella Angela TITLE=Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases JOURNAL=Frontiers in Pharmacology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00162 DOI=10.3389/fphar.2017.00162 ISSN=1663-9812 ABSTRACT=
Bile acid (BA) receptors represent well-defined targets for the development of novel therapeutic approaches to metabolic and inflammatory diseases. In the present study, we report the generation of novel C-3 modified 6-ethylcholane derivatives. The pharmacological characterization and molecular docking studies for the structure-activity rationalization, allowed the identification of 3β-azido-6α-ethyl-7α-hydroxy-5β-cholan-24-oic acid (compound