AUTHOR=Kamisoglu Kubra , Acevedo Alison , Almon Richard R. , Coyle Susette , Corbett Siobhan , Dubois Debra C. , Nguyen Tung T. , Jusko William J. , Androulakis Ioannis P. TITLE=Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels JOURNAL=Frontiers in Pharmacology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00091 DOI=10.3389/fphar.2017.00091 ISSN=1663-9812 ABSTRACT=

In this paper, we discuss approaches for integrating biological information reflecting diverse physiologic levels. In particular, we explore statistical and model-based methods for integrating transcriptomic, proteomic and metabolomics data. Our case studies reflect responses to a systemic inflammatory stimulus and in response to an anti-inflammatory treatment. Our paper serves partly as a review of existing methods and partly as a means to demonstrate, using case studies related to human endotoxemia and response to methylprednisolone (MPL) treatment, how specific questions may require specific methods, thus emphasizing the non-uniqueness of the approaches. Finally, we explore novel ways for integrating -omics information with PKPD models, toward the development of more integrated pharmacology models.