AUTHOR=Saletti Patricia G., Maior Rafael S., Hori Etsuro , Nishijo Hisao , Tomaz Carlos TITLE=Sensorimotor gating impairments induced by MK-801 treatment may be reduced by tolerance effect and by familiarization in monkeys JOURNAL=Frontiers in Pharmacology VOLUME=Volume 6 - 2015 YEAR=2015 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2015.00204 DOI=10.3389/fphar.2015.00204 ISSN=1663-9812 ABSTRACT=
Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate MK-801 effects on monkeys’ PPI, we tested eight capuchin monkeys (