AUTHOR=Mancuso Cesare , Gaetani Silvana TITLE=Preclinical and clinical issues in Alzheimer's disease drug research and development JOURNAL=Frontiers in Pharmacology VOLUME=5 YEAR=2014 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2014.00234 DOI=10.3389/fphar.2014.00234 ISSN=1663-9812