AUTHOR=Wang Xinmin , Peng Yunru , Jing Xinyue , Qian Dawei , Tang Yuping , Duan Jin-ao TITLE=In vitro and in vivo assessment of CYP2C9-mediated herb–herb interaction of Euphorbiae Pekinensis Radix and Glycyrrhizae Radix JOURNAL=Frontiers in Pharmacology VOLUME=5 YEAR=2014 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2014.00186 DOI=10.3389/fphar.2014.00186 ISSN=1663-9812 ABSTRACT=
According to traditional Chinese medicine theories, Euphorbiae Pekinensis Radix and Glycyrrhizae Radix should not be used together in one prescription, because their interaction leads to an unexpected consequence. However, the mechanism remains unclear. The purpose of this study was to find out whether CYP2C9 was involved in this herb–herb interaction by using tolbutamide as a probe substrate