AUTHOR=Piacentini Roberto , De Chiara Giovanna , Li Puma Domenica D. , Ripoli Cristian , Marcocci Maria E. , Garaci Enrico , Palamara Anna T. , Grassi Claudio 

TITLE=HSV-1 and Alzheimer’s disease: more than a hypothesis

JOURNAL=Frontiers in Pharmacology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2014.00097

DOI=10.3389/fphar.2014.00097

ISSN=1663-9812

ABSTRACT=<p>Among the multiple factors concurring to Alzheimer’s disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.</p>