AUTHOR=Zhang Li , Jin Yi , Huang Meng , Penning Trevor M. TITLE=The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones JOURNAL=Frontiers in Pharmacology VOLUME=Volume 3 - 2012 YEAR=2012 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2012.00193 DOI=10.3389/fphar.2012.00193 ISSN=1663-9812 ABSTRACT=
Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants. They are procarcinogens requiring metabolic activation to elicit their deleterious effects. Aldo-keto reductases (AKR) catalyze the oxidation of proximate carcinogenic PAH