AUTHOR=Inchauspe Adrián Angel A.

TITLE=Torsadogenic Index: A Proposal to Improve Survival Rates in Cardiac Arrests Due to Prescribed Drugs

JOURNAL=Frontiers in Pharmacology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2012.00099

DOI=10.3389/fphar.2012.00099

ISSN=1663-9812

ABSTRACT=<p>Since unexpected sudden deaths have been reported with the use of diverse non-cardiac drugs, cardio-safety experts focused their attention on security measures to improve survival rates in heart stoppages due to this prescribed drugs (Inchauspe <xref ref-type="bibr" rid="B4">2010a</xref>). Considering that prolongation of the QTc is a reliable marker of a menacing arrhythmia called torsade de pointes (TdP) – that can progress to ventricular fibrillation, application of Bazett, or Rautaharhu formulas can lead to a proper predictive valuation of a “torsadogenic risk.” Case-analysis raises up the proposal that QTc or QTp will allow to identify high risk groups; performs a close pharmaco-vigilance and legally register ECG follow-up, avoiding unnecessary withdrawal of useful drugs from market.</p>