AUTHOR=Cicchetti Francesca , Barker Roger A. TITLE=Current Understanding of the Glial Response to Disorders of the Aging CNS JOURNAL=Frontiers in Pharmacology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2012.00095 DOI=10.3389/fphar.2012.00095 ISSN=1663-9812 ABSTRACT=

In this special issue of Frontiers in Pharmacology, we have asked leading experts to comment and review the evidence that inflammatory cells play a leading role in the pathological processes underlying neurodegenerative disorders. We now seek to draw these various observations together into a conclusion, with the hope that this will inform further work in this area and result in the identification of new therapeutic targets that will have a disease modifying effect.