AUTHOR=Zhao Ting , Li Dong-Jie , Liu Chong , Su Ding-Feng , Shen Fu-Ming 

TITLE=Beneficial Effects of Anisodamine in Shock Involved Cholinergic Anti-Inflammatory Pathway

JOURNAL=Frontiers in Pharmacology

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2011.00023

DOI=10.3389/fphar.2011.00023

ISSN=1663-9812

ABSTRACT=<p>Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965. The main mechanism of anisodamine for anti-shock proposed in <italic>Pharmacology</italic> for Chinese medical students is to improve blood flow in the microcirculation. Here, we suggest a new mechanism for its anti-shock effect. That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway.</p>