AUTHOR=Zhang Jian , Gong Yanjun , Yu Ying 

TITLE=PG F2α Receptor: A Promising Therapeutic Target for Cardiovascular Disease

JOURNAL=Frontiers in Pharmacology

VOLUME=1

YEAR=2010

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2010.00116

DOI=10.3389/fphar.2010.00116

ISSN=1663-9812

ABSTRACT=<p>Prostaglandins (PGs), a group of key lipid mediators, are involved in numerous physiological and pathological processes including inflammation and cardiovascular homeostasis. Each PG acts on its specific and distinct cell surface G protein-coupled receptors (GPCRs) or peroxisome proliferator-activated receptors (PPARs). Prostaglandin F<sub>2α</sub> receptor (FP) is required for female reproductive function such as luteolysis and parturition. It has recently been implicated in blood pressure regulation, atherosclerosis and other inflammation-related disorders. The emerging role of FP in cardiovascular diseases is highlighted and potential therapeutic translation is discussed in the current review.
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