https://www.frontiersin.org/journals/pediatrics/sections/pediatric-nephrology RSS Feed for Pediatric Nephrology section in the Frontiers in Pediatrics journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-14T17:28:04.981+00:00 60 https://www.frontiersin.org/articles/10.3389/fped.2026.1699921 https://www.frontiersin.org/articles/10.3389/fped.2026.1699921 2026-05-12T00:00:00Z Original Research Gaetano CiancioJeffrey J. GaynorMahmoud MorsiAngel AlvarezMatthew GaynorMarissa DefreitasJayanthi Chandar https://www.frontiersin.org/articles/10.3389/fped.2026.1757626 https://www.frontiersin.org/articles/10.3389/fped.2026.1757626 2026-04-30T00:00:00Z Original Research Gunes IsikCemil Oktay 15 mm).ResultsAmong 341 patients (71.3% male), 36.2% had severe and 63.8% had mild-to-moderate urinary tract dilation. Mean AP diameter was 14.4 ± 7.0 mm. Urinary tract dilation resolved in 96.2% of patients, typically within 3–44 months (mean 11 ± 6.3). Surgery was required in 22.6% of patients, mostly for ureteropelvic junction obstruction and vesicoureteral reflux, and was significantly more common in severe cases (56.1% vs. 3.7%, p < 0.001). Severe urinary tract dilation was significantly associated with family history of congenital anomalies of the kidney and urinary tract, history of urinary tract infection (UTI), reduced kidney function, and abnormal dimercaptosuccinic acid renal scintigraphy findings (p < 0.001). ROC analysis demonstrated high predictive performance (area under the receiver operating characteristic curve (AUC) = 0.936, 95% confidence interval: 0.908–0.963; p < 0.001). An AP diameter cutoff value of 17 mm predicted surgical intervention, with 88.3% sensitivity and 84.1% specificity.ConclusionAn AP diameter ≥17 mm, decreased differential kidney function, UTI history, and family history of congenital anomalies of the kidney and urinary tract are strong indicators for surgical intervention.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1774632 https://www.frontiersin.org/articles/10.3389/fped.2026.1774632 2026-04-30T00:00:00Z Case Report Hongcai MaHuijiao HanYanyan LiuYong An T (p.Arg652*), in NR3C2, confirming the diagnosis. Aggressive sodium supplementation corrected the electrolyte imbalance, and follow-up showed normal growth and stable serum sodium. This case underscores the need to consider inherited renal tubulopathies in neonates with refractory hyponatraemia and highlights the pivotal role of genetic testing in precise diagnosis.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1779651 https://www.frontiersin.org/articles/10.3389/fped.2026.1779651 2026-04-28T00:00:00Z Review Viola WeedaNikolaos KoliakosThomas CaësAdrian KhelifDimitri MikhalskiPierre Lingier https://www.frontiersin.org/articles/10.3389/fped.2026.1753010 https://www.frontiersin.org/articles/10.3389/fped.2026.1753010 2026-04-22T00:00:00Z Original Research Yanan HanYanjun YangPeitong HanXiaoying YuanChunzhen LiJieyuan Cui https://www.frontiersin.org/articles/10.3389/fped.2026.1838282 https://www.frontiersin.org/articles/10.3389/fped.2026.1838282 2026-04-15T00:00:00Z Correction Eun Song SongEun Mi Yang https://www.frontiersin.org/articles/10.3389/fped.2026.1767283 https://www.frontiersin.org/articles/10.3389/fped.2026.1767283 2026-04-15T00:00:00Z Original Research Wenyan WangFei ZhaoGuixia DingSanlong ZhaoGuoliang MaXueqin Cheng  0.05).ConclusionRepeat kidney biopsy detects pathological progression (e.g., increased chronicity) and guides treatment modifications in over 60% of pediatric LN cases. However, pathological class change alone does not dictate short-term outcomes, highlighting initial treatment response as a stronger prognostic indicator. Individualized use of repeat biopsies is recommended for children with proteinuria relapse to optimize management while mitigating procedural invasiveness.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1790656 https://www.frontiersin.org/articles/10.3389/fped.2026.1790656 2026-04-14T00:00:00Z Case Report Xiaoyu QiaoYanyu ChenDanyan SuLifeng ShangYusheng Pang https://www.frontiersin.org/articles/10.3389/fped.2026.1671377 https://www.frontiersin.org/articles/10.3389/fped.2026.1671377 2026-04-08T00:00:00Z Original Research Ying LiangYing ShenYeping Jiang 3 mg/L) was an independent risk factor for PEW (OR = 2.86, 95% CI: 1.52–5.38, P = 0.001).ConclusionPEW is highly prevalent in advanced pediatric CKD, driven by inflammation and nutritional deficits, and acts as an independent predictor of growth retardation. Early screening and stage-specific, evidence-based dietary and pharmacological interventions in accordance with the 2020 KDOQI guidelines are imperative to mitigate morbidity, particularly for stage 5 non-dialysis patients with low access to standardized nutritional care.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1712781 https://www.frontiersin.org/articles/10.3389/fped.2026.1712781 2026-03-27T00:00:00Z Original Research Ying LiangYing ShenYeping Jiang https://www.frontiersin.org/articles/10.3389/fped.2026.1706611 https://www.frontiersin.org/articles/10.3389/fped.2026.1706611 2026-03-12T00:00:00Z Original Research Yue CaiYing-qi LinXin-yu KuangLei SunMeng-ying LiYu-jie HuWen-yan Huang https://www.frontiersin.org/articles/10.3389/fped.2026.1779744 https://www.frontiersin.org/articles/10.3389/fped.2026.1779744 2026-03-06T00:00:00Z Original Research Mihriban İnözüSibel Çetince ŞensesÖzlem Yüksel AksoyBurcu YazıcıoğluSare Gülfem ÖzlüFatma Şemsa ÇaycıUmut Selda Bayrakçı https://www.frontiersin.org/articles/10.3389/fped.2026.1740485 https://www.frontiersin.org/articles/10.3389/fped.2026.1740485 2026-02-26T00:00:00Z Case Report Hua SongYi LinYuwei Xian T (p.Gly2786Val) (maternal) and IVS54+3A>C (paternal) (NM_000051). Cystoscopy revealed multiple telangiectatic lesions of the bladder mucosa with associated yellow-brown sedimentation. Emergency cystoscopic electrocoagulation controlled the bleeding.ConclusionWe report two novel ATM variants (c.8357G>T, IVS54+3A>C) in a patient with classic AT who developed severe hemorrhagic cystitis associated with bladder wall telangiectasia. AT patients may be at risk for delayed, potentially life-threatening hemorrhagic cystitis, particularly following cyclophosphamide exposure. Cystoscopy is essential for diagnosis and enables timely endoscopic management.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1714324 https://www.frontiersin.org/articles/10.3389/fped.2026.1714324 2026-02-16T00:00:00Z Original Research Josephine Reinert QuistLeigh C. WardLars JødalRené Frydensbjerg AndersenChristian Lodberg HvasSteven Brantlov https://www.frontiersin.org/articles/10.3389/fped.2026.1690215 https://www.frontiersin.org/articles/10.3389/fped.2026.1690215 2026-01-29T00:00:00Z Case Report Dengyan WuLina MaHuimin WuJie LiJing YangLi Huang https://www.frontiersin.org/articles/10.3389/fped.2025.1710286 https://www.frontiersin.org/articles/10.3389/fped.2025.1710286 2026-01-27T00:00:00Z Case Report Takuji EnyaKohei MiyazakiSakina KugeYuichi MorimotoHiroki KondouNaoki SakataKensuke JohChina NaganoKandai NozuNobutoshi ItoYoshiyuki HakataKeisuke SugimotoMasaaki Miyazawa C (p.Met1604Thr), resulting in an M1604T substitution in the functional C345C domain. Molecular structural analyses indicated that this amino acid substitution can cause the formation of a large cavity within the hydrophobic core of the C-terminal domain, possibly destabilizing the spherical structure of C3. Our study highlights that the M1604T substitution in the C3 C345C domain may drive the observed excessive complement activation, C5b-9 deposition on endothelial cells, and severe circulatory disturbances in the intestinal mucosa.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1737399 https://www.frontiersin.org/articles/10.3389/fped.2026.1737399 2026-01-22T00:00:00Z Case Report Eun Song SongEun Mi Yang https://www.frontiersin.org/articles/10.3389/fped.2025.1728887 https://www.frontiersin.org/articles/10.3389/fped.2025.1728887 2026-01-22T00:00:00Z Case Report Yuxuan GuLe WangXiaoying YuanYanan HanPeitong HanJieyuan CuiXinlei WangYuchan HuangLili ZhangChunzhen Li https://www.frontiersin.org/articles/10.3389/fped.2025.1709402 https://www.frontiersin.org/articles/10.3389/fped.2025.1709402 2026-01-15T00:00:00Z Systematic Review Xilin Xiong  0.05). Funnel plots suggested minimal publication bias.ConclusionCombination therapies, especially tacrolimus + GC and MMF + GC, offer greater efficacy than GC monotherapy in pediatric IgAN, without increasing adverse events. These findings support their clinical application, though larger studies are needed to validate results and optimize treatment strategies.]]> https://www.frontiersin.org/articles/10.3389/fped.2025.1755954 https://www.frontiersin.org/articles/10.3389/fped.2025.1755954 2026-01-15T00:00:00Z Original Research Ping BaiLili LiuDiyi Luo