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ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 13 - 2025 | doi: 10.3389/fped.2025.1568174
This article is part of the Research Topic Celiac Disease In Children View all 4 articles
Allergic and Immunologic Evaluation of Children with Celiac Disease
Provisionally accepted
Duygu Demirtaş Güner 1*
Kübra Baskın 2- 1 Department of Pediatric Gastroenterology, Hepatology and Nutrition, Dr. Behçet Uz Children’s Hospital, Izmir, Türkiye
- 2 Department of Pediatric Allergy and Immunology, Gazi University, Ankara, Ankara, Türkiye
Introduction: Celiac disease (CD) and allergic diseases are immune-mediated disorders with overlapping clinical and immunologic features. The association between CD and selective immunoglobulin (Ig) A deficiency (sIgAD) is well-established, but limited data exist on the relationship between CD, other antibody deficiencies, and allergic diseases in children. This study aimed to evaluate the prevalence of allergic manifestations and immunologic abnormalities in children with CD.Methods: This prospective study included children with biopsy-confirmed CD, followed at a gastroenterology clinic from August 2022 to February 2023. Participants underwent comprehensive immunologic and allergic evaluation, including serum immunoglobulin levels, vaccine antibody responses, lymphocyte subgroup analysis, and allergy testing as clinically indicated.Results: The cohort included 76 patients with a median age of 11 years and a median age at CD diagnosis of 5.8 years. Allergic manifestations included aeroallergen sensitivity (22.4%), allergic rhinitis (15.8%), allergic conjunctivitis (13.2%), food allergy (5.3%), and asthma and eczema (3.9% each). Immunologic evaluations revealed normal profiles in 69.7% of patients, while abnormalities included partial IgM deficiency (6.6%), unclassified hypogammaglobulinemia (5.3%), sIgAD (2.6%), and transient hypogammaglobulinemia of infancy (2.6%). Elevated IgE levels were observed in 13.2% of patients.Conclusion: This study highlighted a significant prevalence of allergic diseases and immunologic abnormalities in children with CD, extending beyond the commonly recognized association with sIgAD. These findings underscore the importance of comprehensive immunologic and allergic evaluation in children with CD.
Keywords: allergy, Antibody deficiency, Celiac Disease, Children, immunodeficiency, Immune dysregulation
Received: 28 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Demirtaş Güner and Baskın. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Duygu Demirtaş Güner, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Dr. Behçet Uz Children’s Hospital, Izmir, Türkiye
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