Brett J. Hoskins- Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at IU Health, Indianapolis, IN, United States
Deep enteroscopy, encompassing push enteroscopy (PE) and balloon-assisted enteroscopy (BAE), has revolutionized the diagnosis and treatment of pediatric small bowel disorders. This review examines the evolving role of these techniques in managing conditions such as obscure gastrointestinal bleeding, Crohn's disease, polyposis syndromes, strictures, and small bowel tumors. While PE is effective for both diagnostic and therapeutic interventions in the proximal small bowel, its limited insertion depth has driven the adoption of BAE techniques. These include single-balloon enteroscopy (SBE) and double-balloon enteroscopy (DBE), which provide deeper and more comprehensive access. Both BAE modalities offer greater insertion depth and stability, enabling advanced therapeutic interventions such as polypectomy, stricture dilation, and hemostasis. Pediatric-specific data demonstrate high diagnostic yields for BAE, with comparable outcomes between SBE and DBE. These techniques have proven safe across diverse indications, though younger children may experience slightly higher complication rates due to anatomical considerations. Despite these advancements, challenges persist, including a limited evidence base in pediatrics, barriers to training, and the need for standardized protocols. Additionally, emerging innovations such as artificial intelligence offer opportunities to enhance diagnostic accuracy and procedural efficiency. Comparative analyses of PE, BAE, and capsule endoscopy are necessary to refine procedural selection and optimize outcomes in pediatric patients. Furthermore, structured pediatric training programs and simulation-based learning could address competency gaps, ensuring safe and effective application of these techniques. By addressing current research gaps, embracing technological advancements, and tailoring approaches to pediatric populations, deep enteroscopy can continue to transform the management of small bowel disorders in children.
Introduction
Deep enteroscopy encompasses push enteroscopy (PE) and balloon-assisted enteroscopy (BAE), which includes single-balloon enteroscopy (SBE) and double-balloon enteroscopy (DBE). These advanced techniques have transformed the diagnostic and therapeutic management of pediatric small bowel disorders, allowing for interventions that were previously limited to surgical approaches (1–5). While BAE enables deeper and more comprehensive access to the small intestine, its complexity and technical demands necessitate specialized expertise and training. Consequently, its availability is largely limited to high-volume centers, posing challenges for widespread implementation in pediatric gastroenterology. Additionally, the small intestine's intricate anatomy and unique physiological characteristics in children necessitate a meticulous and tailored approach to ensure procedural success (2, 6, 7).
The development of capsule endoscopy, a minimally-invasive imaging modality, served as a catalyst for deep enteroscopy by highlighting the need for direct visualization and intervention (2, 4, 8–10). Today, deep enteroscopy is an indispensable tool in the management of pediatric conditions such as obscure gastrointestinal bleeding (OGIB), polyposis syndromes, Crohn's disease, strictures, Meckel's diverticula, and small bowel tumors. Beyond diagnostics, it facilitates therapeutic interventions, including polypectomy, hemostasis, stricture dilation, foreign body retrieval, defect closure, and even endoscopic cholangioscopy in children with altered anatomy (1–4, 6, 7, 9–20).
Although PE provided early capabilities for small bowel evaluation (2, 9, 21), its limited insertion depth led to the development of balloon-assisted techniques like SBE and DBE. These methods achieve deeper insertion and greater therapeutic stability using overtubes with inflatable balloons to pleat the small bowel onto the endoscope (3, 6, 22). Depending on the target area within the small intestine, procedures can be performed anterograde (oral) or retrograde (rectal) (1, 6). While spiral enteroscopy (SE) is effective in adults, its application in pediatrics remains limited due to equipment constraints and sparse data (6).
This review examined the pediatric literature on deep enteroscopy, analyzing its indications, methodologies, outcomes, and challenges while highlighting its evolving role in small bowel disease management. Tables 1–3 provide detailed comparisons of PE, SBE, and/or DBE, outlining their respective insertion methods, equipment specifications, depth of insertion, diagnostic yields, therapeutic applications, and procedural limitations. This comparative framework lays the foundation for the subsequent in-depth exploration of each modality.
Table 1. Comparison of push enteroscopy, single-balloon enteroscopy, and double-balloon enteroscopy in children.
Table 2. Summary of balloon-assisted enteroscopy studies in children.
Table 3. Equipment specifications for balloon-assisted enteroscopes.
Push Enteroscopy (PE)
PE is a minimally-invasive technique that utilizes a flexible endoscope to access deeper sections of the small bowel via an advance-and-reduce (push-and-pull) method. It is commonly performed antegrade in the upper gastrointestinal tract for proximal small bowel conditions, but can also be performed retrograde via the anal route to access the distal small bowel.
Equipment specifics
PE can be performed using either a dedicated enteroscope or a pediatric or adult colonoscope (23, 24). Several push enteroscope models are available from manufacturers such as Olympus, Fujinon, and Pentax, featuring working lengths of 150–250 cm, outer diameters of 9.2–11.7 mm, and working channel diameters of 2.8–3.8 mm (24, 25). Equipment specifics for pediatric and adult colonoscopes vary depending on the manufacturer, and can provide an additional 23–67 cm of working length compared to gastroscopes. Overtubes may be used to decrease gastric looping and enable deeper insertion (25).
Clinical applications
PE is an effective diagnostic and therapeutic tool for managing proximal small bowel conditions in pediatric patients, including OGIB, ulcers, strictures, polyps, and lymphangiectasia (9, 11, 21, 23). It can help diagnose Crohn's disease, polyps, eosinophilic gastroenteritis, and other conditions, significantly influencing clinical management (21).
In adult studies, PE is used for evaluating abnormal imaging, localizing and treating lesions, sampling tumors, managing polyposis syndromes, retrieving foreign bodies, facilitating ERCP in postsurgical anatomy, placing jejunostomy tubes, and addressing chronic diarrhea and malabsorption (8, 26). The American Society for Gastrointestinal Endoscopy (ASGE) guidelines highlight its diagnostic and therapeutic utility for small bowel bleeding, with diagnostic yields ranging from 24%–56% (27). For OGIB specifically, PE identifies bleeding sources in the proximal small intestine and provides therapeutic options, improving outcomes while minimizing invasiveness (27, 28). Although pediatric-specific data are limited, adult studies report diagnostic yields ranging from 3%–70%, depending on insertion depth and lesion location (29). An early study by Darbari et al. showed a diagnostic yield of 84% in 44 children (21).
In pediatric studies, insertion depths of 132 cm beyond the pylorus were achieved using an SIF-190 enteroscope (Olympus America Inc., Center Valley, PA) in children as young as 2 years of age and weighing at least 10 kg (21). According to American College of Gastroenterology (ACG) guidelines, PE typically advances 45–90 cm beyond the ligament of Treitz (29).
PE is valuable in pediatric Crohn's disease, enabling biopsies and therapeutic stricture dilation (9, 11). It also facilitates polypectomy for syndromes like Peutz-Jeghers syndrome (PJS) and familial adenomatous polyposis, effectively removing duodenal/jejunal polyps and reducing surgical interventions (21). These findings position PE as a minimally invasive, versatile option for pediatric small bowel disorders.
Safety and adverse events
PE is generally considered safe in pediatric patients, although data specific to this population remain limited. In a study by Darbari et al., PE was safely performed in 44 children (median age: 10 years) without any significant adverse events. Minor complications, such as transient abdominal pain and discomfort, were the most commonly reported issues (21).
While pediatric-specific data are sparse, adult studies offer additional insight into PE's safety profile. In adults, the overall complication rate is low, with major events like perforation and bleeding occurring in less than 1% of cases (30). Other potential complications include infection and sedation-related cardiopulmonary events. According to ACG guidelines, careful patient selection and procedural technique further minimize risks (29).
Although larger pediatric studies are needed, current evidence supports PE as a safe procedure for evaluating and managing proximal small bowel conditions in children, with a low incidence of significant complications.
Training and implementation
Effective use of PE requires advanced training, though its learning curve is less steep compared to modalities with specialized equipment. Pediatric endoscopists typically gain proficiency through observation, mentorship, and simulation-based modules designed to replicate small bowel navigation techniques (31). The ASGE 2013 guidelines recommend training programs combining virtual and hands-on experience under expert supervision to enhance procedural skills and confidence (31). Similarly, the European Society of Gastrointestinal Endoscopy (ESGE) recommends a minimum of 75 procedures to achieve competence in device-assisted enteroscopy (DAE) (32), which can be particularly challenging in the pediatric population due to the fewer cases available.
While equipment costs can be challenging, using a colonoscope in certain cases helps reduce expenses. PE's ability to replace exploratory surgery and provide therapeutic interventions offers significant long-term healthcare savings (33, 34). Training also emphasizes careful patient selection, proper techniques, and effective complication management to ensure safety and optimize outcomes (35).
Research gaps
While PE has been adopted in pediatrics, its use remains somewhat limited by the lack of robust pediatric-specific studies. One study demonstrated its safety and diagnostic utility in children (21), though larger multicenter trials are needed to fully evaluate its safety, efficacy, and long-term outcomes in this population. Furthermore, differences in anatomy, physiology, and disease manifestations between adults and children challenge the direct extrapolation of adult findings, highlighting the need for dedicated pediatric research.
Balloon-Assisted Enteroscopy (BAE)
BAE uses an overtube equipped with either one or two inflatable balloons to achieve incremental advancement of the endoscope, allowing for deep intubation of the small bowel. This technique offers superior depth of insertion compared to traditional methods, making it a crucial tool for diagnosing and managing small bowel disorders in children. The two primary modalities, SBE and DBE, are widely utilized to address mid-to-distal small bowel pathologies. Although DBE was initially thought to achieve greater insertion depth, recent evidence demonstrates that the outcomes of SBE and DBE are comparable (36–38).
Equipment specifics
The equipment used for BAE varies between SBE and DBE, each with specific features designed to optimize performance. SBE employs a single balloon on the overtube to anchor the bowel and pleat it over the endoscope. Models such as the Olympus SIF-H190 (Olympus America, Inc., Center Valley, PA, USA) feature a 9.2 mm outer diameter, a working length of 200 cm, and a 3.2 mm instrument channel, while the slightly older SIF-Q260 model offers similar specifications but with a smaller 2.8 mm instrument channel. Both models are compatible with the ST-SB1 splinting tube, available in silicone, which has an outer diameter of 13.2 mm and a working length of 132 cm (29, 39–41).
In contrast, DBE uses two balloons—one on the overtube and another on the endoscope itself—to facilitate a push-and-pull technique. Fujifilm (Valhalla, NY, USA) offers multiple models, including the EN-580 T (standard/therapeutic), EN-580XP (slim), and EI-580BT (short). These models range in outer diameters from 7.5 mm for the slim version to 9.4 mm for the standard and short versions, with working lengths of 155–200 cm and instrument channels ranging from 2.2–3.2 mm. Other models are also available. Like SBE, DBE systems require a balloon control unit for operation, and compatible overtubes are available in latex or silicone, with diameters tailored to the endoscope type (7, 41).
Clinical applications
BAE has diverse applications in pediatrics, including both diagnostic and therapeutic uses. Indications include OGIB, ulcers, strictures, polyps, lymphangiectasia, chronic abdominal pain, chronic diarrhea, malabsorption syndromes, tumors, and eosinophilic enteritis, foreign body retrieval, post-small bowel transplantation evaluation, and jejunostomy tube placement (1, 2, 4, 5, 7, 12, 15, 16, 29, 41–48). In pediatric Crohn's disease, BAE facilitates targeted biopsies and therapeutic interventions like stricture dilation, reducing surgical interventions and guiding therapy (2, 5, 12, 29). For PJS, it enables safe and effective polypectomy, preventing complications like intussusception and bowel obstruction (46, 47).
Beyond its role in primary small bowel disorders, BAE is also useful in children with post-surgical or altered anatomy, where conventional endoscopy may be limited. It has been successfully used after procedures such as proctocolectomy, ileocecectomy, small bowel resection, serial transverse enteroplasty, and Roux-en-Y hepaticojejunostomy, with studies supporting its safety and efficacy (7, 45). One study reported that pediatric DBE can be safely performed postoperatively, though insertion challenges may arise due to adhesions, stenosis, or thickened bowel walls (45).
Diagnostic yields for SBE vary, with studies reporting rates of 47%–74% with no major adverse events (4, 5, 29, 41). DBE shows similar diagnostic yields, ranging from 58.8%–78.6% in pediatric cohorts, with therapeutic interventions in 46.5–76.9% of cases (1, 7, 15, 16, 48). Its ability to achieve deep intubation is advantageous for mid-to-distal small bowel pathologies, including polypectomy and stricture management (41, 47). Studies report SBE use in children ≥3 years and ≥13.5 kg (5, 42), and DBE in children ≥2 years and ≥12 kg (4, 15).
Comparison of SBE and DBE
Although early studies suggested that DBE offered greater depth of insertion than SBE, more recent evidence indicates that the two techniques achieve comparable outcomes. A randomized multicenter trial by Domagk et al. reported mean oral intubation depths of 253 cm for DBE and 258 cm for SBE (49). Similarly, Efthymiou et al. found no significant difference between the two, with mean depths of 203.8 cm for SBE and 234.1 cm for DBE (36). A systematic review and meta-analysis by Lipka et al. confirmed these findings, showing no significant differences in anterograde or retrograde insertion depths between the two modalities (37). The choice between SBE and DBE is often determined by institutional availability, operator expertise, and the specific clinical indication, although some studies indicate DBE's dual balloons may provide enhanced therapeutic stability (50, 51).
Safety and adverse events
BAE has a strong safety profile in pediatric patients, with low rates of major complications reported for both SBE and DBE, though outcomes may vary by patient population, procedural route, and clinical indication.
For SBE, multiple studies demonstrate excellent safety. Reddy et al. evaluated 189 SBE procedures in 174 children and reported no major adverse events, with minor issues such as transient abdominal pain being the most commonly observed complication (5). Similarly, Di Nardo et al. reviewed SBE use in children with Crohn's disease and reported no complications, further reinforcing the procedure's safety in this population (12). Among children with PJS, Bizzarri et al. reported mild abdominal pain in three cases and a single instance of post-polypectomy perforation out of 23 procedures. This perforation was managed conservatively without long-term complications, highlighting the relative safety of SBE for polypectomy in pediatric PJS patients (46). Li et al. also evaluated 41 children undergoing BAE for PJS and noted an overall complication rate of 1.2%, with 1.8% for BAE-facilitated polypectomy, supporting its safety in this high-risk population (14). Barth and Channabasappa similarly found no serious complications in their initial experience of SBE, concluding that SBE was both feasible and safe in children (52).
DBE shows a similarly favorable profile, though younger children may experience slightly higher minor complication rates. Yokoyama et al. reviewed 257 DBE procedures in 117 children, including DBE-cholangioscopy cases, and reported an overall complication rate of 5.4%, which increased to 10.4% in children under 10 years. Adverse events consisted of one case of post-polypectomy perforation and four cases of post-polypectomy bleeding (15). Chen et al. found no serious complications in 72 DBE procedures performed in 61 children, with minor issues like self-limited discomfort most common (48). Urs et al. reported complications in 5.2% of 113 DBE procedures in 58 children, all resolving without long-term sequelae (16). Lin and Erdman observed no major complications in 13 DBE procedures (43), and Nishimura et al. reported one case of post-polypectomy bleeding among 92 DBE procedures in pediatric patients (7).
A multicenter prospective study by Hagiwara et al. reviewed 96 procedures in pediatric patients and reported two severe adverse events: one case of bleeding after polypectomy and one instance of pancreatitis following retrograde DBE cholangioscopy. No intestinal perforations were observed, and the overall severe complication rate remained low (4).
While younger children, particularly those under 10 years, may experience slightly higher complication rates due to anatomical differences, BAE remains a safe and effective diagnostic and therapeutic tool in pediatric patients. In the available data, serious complications such as bleeding and perforation are rare and almost exclusively occur following polypectomy or other therapeutic interventions. Careful patient selection and procedural precision are essential to mitigate these risks.
Training and implementation
Training and implementation of pediatric SBE and DBE require a structured educational framework and adherence to established clinical guidelines to ensure procedural safety and optimize patient outcomes. Competency is typically developed through a combination of clinical experience and simulation-based training, although no validated criteria currently exist for determining proficiency (53). Research has demonstrated that simulation-based training enhances technical skill acquisition and improves procedural performance in clinical settings (54–57). However, simulation alone cannot substitute for the hands-on clinical experience required to achieve expertise (58–60).
The ASGE recommends performing at least 10 upper deep enteroscopy cases and 20 retrograde DBE cases to achieve measurable improvements in DAE techniques, such as stable overtube intubation of the ileum. Meeting these minimum case volumes has been associated with greater procedural success, higher rates of complete small bowel examination, and shorter procedure durations (53). The ESGE advises completing at least 75 DAE procedures, including a minimum of 35 retrograde cases, with at least 50% of these involving therapeutic interventions, reflecting a more rigorous approach to competency (32).
Early studies have also highlighted the importance of case volume in building proficiency in DBE. One study demonstrated significant improvements in procedural and fluoroscopy times after 10 cases (61), while another suggested that full DBE expertise may require 100–150 cases (62).
Research directions
BAE has been shown to be a safe and effective diagnostic and therapeutic tool for pediatric small bowel disorders. However, significantly fewer studies are available for SBE compared to DBE, particularly in pediatric populations. Larger multicenter trials are needed to better validate the safety and efficacy of SBE across diverse pediatric cohorts, which would also help refine techniques and protocols to minimize complications and improve patient safety (5, 12).
A critical research gap exists in understanding the comparative effectiveness of PE and BAE in pediatric patients. Although BAE offers greater insertion depth and therapeutic potential, comparative data in children is sparce. While SBE and DBE have shown comparable efficacy in adults, their effectiveness in pediatric populations remains underexplored. Studies are needed to evaluate SBE, DBE, PE, and capsule endoscopy in children, assessing diagnostic yield, therapeutic success, and complication profiles. Such studies would elucidate the advantages, limitations, and indications for each technique, optimizing procedural selection and clarifying the role of non-invasive imaging vs. the therapeutic potential of BAE and PE in pediatric gastroenterology.
Addressing these gaps also requires innovative approaches, including the adoption of emerging technologies to enhance current practices. In adult studies, artificial intelligence (AI) has demonstrated the potential to improve diagnostic accuracy and procedural efficiency, such as through enhanced lesion detection and reduced missed diagnoses (46, 63). Adapting AI for pediatric BAE could increase diagnostic yield, reduce the need for more invasive procedures, and ultimately enhance patient outcomes, helping to overcome some of the current limitations in this field.
Spiral Enteroscopy (SE)
SE is an alternative technique for deep enteroscopy. The Endo-Ease Discovery SB system (Spirus Medical, Stoughton, Massachusetts, USA) uses a helical (spiral) overtube that rotates to pleat the small intestine, enabling deeper intubation. SE offers advantages such as reduced procedure time, easier setup compared to BAE, and a potentially shorter learning curve (31, 64–66). However, no pediatric-specific data exist, and its use in children is limited by the large 16 mm overtube diameter, which is unsuitable for smaller patients (6). Limited evidence and equipment availability currently hinder its adoption in pediatrics. Advances such as smaller-diameter overtubes are needed to evaluate its feasibility in pediatrics.
Discussion
Deep enteroscopy has transformed the diagnostic and therapeutic landscape of pediatric small bowel disorders, providing solutions for conditions previously difficult to manage. Techniques like PE and BAE—encompassing SBE and DBE—have expanded the scope of minimally invasive endoscopy in pediatric gastroenterology. This review highlights advancements these techniques bring, while addressing challenges and future directions.
BAE has revolutionized small bowel diagnostics and therapeutic techniques, enabling interventions like polypectomy, stricture dilation, and hemostasis, reducing reliance on surgery, and improving outcomes. BAE's utility in managing OGIB, polyposis syndromes, and Crohn's disease is well-documented, with high diagnostic yields for SBE and DBE and strong safety profiles in pediatric cohorts.
Tailoring these techniques to pediatric populations remains challenging. Younger children often require procedural modifications due to their smaller size and distinct anatomy. Additionally, there is a scarcity of large-scale studies aimed at developing standardized protocols and conducting comparative evaluations of PE, SBE, DBE, and capsule endoscopy.
Training and competency development barriers include reliance on mentorship and adult-focused training that may not address pediatric-specific nuances. Structured pediatric training programs incorporating simulation could improve procedural skills and safety. Competency benchmarks must also be evaluated for their relevance to pediatric cases.
The future of pediatric deep enteroscopy lies in expanding its evidence base and integrating innovations like AI. Comparative studies are needed to refine procedural selection and tailor interventions. AI-driven diagnostic tools could enhance procedural efficiency and reduce operator dependency.
In conclusion, deep enteroscopy is indispensable for managing pediatric small bowel disorders. By addressing research gaps, refining training, and embracing innovations, its use in pediatrics can be further optimized, ensuring improved outcomes for children.
Author contributions
BH: Writing – original draft, Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The handling editor KN declared a past co-authorship with the author BH.
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References
1. Thomson M, Venkatesh K, Elmalik K, van der Veer W, Jaacobs M. Double balloon enteroscopy in children: diagnosis, treatment, and safety. World J Gastroenterol. (2010) 16(1):56–62. doi: 10.3748/wjg.v16.i1.56
2. de Ridder L, Tabbers MM, Escher JC. Small bowel endoscopy in children. Best Pract Res Clin Gastroenterol. (2012) 26(3):337–45. doi: 10.1016/j.bpg.2012.02.001
3. Di Nardo G, Calabrese C, Conti Nibali R, De Matteis A, Casciani E, Martemucci L, et al. Enteroscopy in children. United European Gastroenterol J. (2018) 6(7):961–9. doi: 10.1177/2050640618789853
4. Hagiwara SI, Kudo T, Kakuta F, Inoue M, Yokoyama K, Umetsu S, et al. Clinical safety and utility of pediatric balloon-assisted enteroscopy: a multicenter prospective study in Japan. J Pediatr Gastroenterol Nutr. (2019) 68(3):306–10. doi: 10.1097/MPG.0000000000002181
5. Reddy PM, Kulkarni S, Nabi Z, Kasle S, Chavan R, Pal P, et al. Single balloon enteroscopy in children for evaluation of small bowel diseases in children: a large, tertiary center study. J Pediatr Surg. (2021) 56(11):2005–9. doi: 10.1016/j.jpedsurg.2020.10.025
6. Barth BA. Enteroscopy in children. Curr Opin Pediatr. (2011) 23(5):530–4. doi: 10.1097/MOP.0b013e32834a1b61
7. Nishimura N, Yamamoto H, Yano T, Hayashi Y, Arashiro M, Miyata T, et al. Safety and efficacy of double-balloon enteroscopy in pediatric patients. Gastrointest Endosc. (2010) 71(2):287–94. doi: 10.1016/j.gie.2009.08.010
8. ASGE Standards of Practice Committee, Shen B, Khan K, Ikenberry SO, Anderson MA, Banerjee S, et al. The role of endoscopy in the management of patients with diarrhea. Gastrointest Endosc. (2010) 71(6):887–92. doi: 10.1016/j.gie.2009.11.025
9. Di Nardo G, de Ridder L, Oliva S, Casciani E, Escher JC, Cucchiara S. Enteroscopy in paediatric crohn’s disease. Dig Liver Dis. (2013) 45(5):351–5. doi: 10.1016/j.dld.2012.07.020
10. Oliva S, Pennazio M, Cohen SA, Aloi M, Barabino A, Hassan C, et al. Capsule endoscopy followed by single balloon enteroscopy in children with obscure gastrointestinal bleeding: a combined approach. Dig Liver Dis. (2015) 47(2):125–30. doi: 10.1016/j.dld.2014.09.001
11. Pohl J, May A, Nachbar L, Ell C. Diagnostic and therapeutic yield of push-and-pull enteroscopy for symptomatic small bowel crohn’s disease strictures. Eur J Gastroenterol Hepatol. (2007) 19(7):529–34. doi: 10.1097/MEG.0b013e328012b0d0
12. Di Nardo G, Oliva S, Aloi M, Rossi P, Casciani E, Masselli G, et al. Usefulness of single-balloon enteroscopy in pediatric crohn’s disease. Gastrointest Endosc. (2012) 75(1):80–6. doi: 10.1016/j.gie.2011.06.021
13. Di Nardo G, Esposito G, Ziparo C, Micheli F, Masoni L, Villa MP, et al. Enteroscopy in children and adults with inflammatory bowel disease. World J Gastroenterol. (2020) 26(39):5944–58. doi: 10.3748/wjg.v26.i39.5944
14. Li BR, Sun T, Li J, Zhang YS, Ning SB, Jin XW, et al. Primary experience of small bowel polypectomy with balloon-assisted enteroscopy in young pediatric peutz-jeghers syndrome patients. Eur J Pediatr. (2020) 179(4):611–7. doi: 10.1007/s00431-019-03534-1
15. Yokoyama K, Yano T, Kumagai H, Mizuta K, Ono S, Imagawa T, et al. Double-balloon enteroscopy for pediatric patients: evaluation of safety and efficacy in 257 cases. J Pediatr Gastroenterol Nutr. (2016) 63(1):34–40. doi: 10.1097/MPG.0000000000001048
16. Urs AN, Martinelli M, Rao P, Thomson MA. Diagnostic and therapeutic utility of double-balloon enteroscopy in children. J Pediatr Gastroenterol Nutr. (2014) 58(2):204–12. doi: 10.1097/MPG.0000000000000192
17. Uchida K, Yoshiyama S, Inoue M, Koike Y, Yasuda H, Fujikawa H, et al. Double balloon enteroscopy for pediatric inflammatory bowel disease. Pediatr Int. (2012) 54(6):806–9. doi: 10.1111/j.1442-200X.2012.03661.x
18. Wu J, Zheng CF, Huang Y, Shao CH, Leung YK. Coordination and nursing care of pediatric patients undergoing double balloon enteroscopy. World J Gastroenterol. (2011) 17(25):3049–53. doi: 10.3748/wjg.v17.i25.3049
19. Gurkan OE, Karakan T, Dogan I, Dalgic B, Unal S. Comparison of double balloon enteroscopy in adults and children. World J Gastroenterol. (2013) 19(29):4726–31. doi: 10.3748/wjg.v19.i29.4726
20. Zhu Z, Zhou S, Cai H, Zhao H, Wang Z. The diagnostic and treatment values of double-balloon enteroscopy in children’s meckel’s diverticular bleeding. Medicine (Baltimore). (2021) 100(10):e24823. doi: 10.1097/MD.0000000000024823
21. Darbari A, Kalloo AN, Cuffari C. Diagnostic yield, safety, and efficacy of push enteroscopy in pediatrics. Gastrointest Endosc. (2006) 64(2):224–8. doi: 10.1016/j.gie.2006.02.039
22. Yamamoto H, Sekine Y, Sato Y, Higashizawa T, Miyata T, Iino S, et al. Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc. (2001) 53(2):216–20. doi: 10.1067/mge.2001.112181
23. Sidhu R, Sanders DS, Morris AJ, McAlindon ME. Guidelines on small bowel enteroscopy and capsule endoscopy in adults. Gut. (2008) 57(1):125–36. doi: 10.1136/gut.2007.129999
24. ASGE Technology Committee, DiSario JA, Petersen BT, Tierney WM, Adler DG, Chand B, et al. Enteroscopes. Gastrointest Endosc. (2007) 66(5):872–80. doi: 10.1016/j.gie.2007.07.032
25. Varadarajulu S, Banerjee S, Barth BA, Desilets DJ, Kaul V, Kethu SR, et al. GI endoscopes. Gastrointest Endosc. (2011) 74(1):1–6.e6. doi: 10.1016/j.gie.2011.01.061
26. ASGE Standards of Practice Committee, Early DS, Ben-Menachem T, Decker GA, Evans JA, Fanelli RD, et al. Appropriate use of GI endoscopy. Gastrointest Endosc. (2012) 75(6):1127–31. doi: 10.1016/j.gie.2012.01.011
27. ASGE Standards of Practice Committee, Gurudu SR, Bruining DH, Acosta RD, Eloubeidi MA, Faulx AL, et al. The role of endoscopy in the management of suspected small-bowel bleeding. Gastrointest Endosc. (2017) 85(1):22–31. doi: 10.1016/j.gie.2016.06.013
28. ASGE Standards of Practice Committee, Fisher L, Lee Krinsky M, Anderson MA, Appalaneni V, Banerjee S, et al. The role of endoscopy in the management of obscure GI bleeding. Gastrointest Endosc. (2010) 72(3):471–9. doi: 10.1016/j.gie.2010.04.032
29. Gerson LB, Fidler JL, Cave DR, Leighton JA. ACG clinical guideline: diagnosis and management of small bowel bleeding. Am J Gastroenterol. (2015) 110(9):1265–87. quiz 1288. doi: 10.1038/ajg.2015.246
30. Levy I, Gralnek IM. Complications of diagnostic colonoscopy, upper endoscopy, and enteroscopy. Best Pract Res Clin Gastroenterol. (2016) 30(5):705–18. doi: 10.1016/j.bpg.2016.09.005
31. ASGE Training Committee 2011–2012, Rajan EA, Pais SA, Degregorio BT, Adler DG, Al-Haddad M, et al. Small-bowel endoscopy core curriculum. Gastrointest Endosc. (2013) 77(1):1–6. doi: 10.1016/j.gie.2012.09.023
32. Sidhu R, Chetcuti Zammit S, Baltes P, Carretero C, Despott EJ, Murino A, et al. Curriculum for small-bowel capsule endoscopy and device-assisted enteroscopy training in Europe: European society of gastrointestinal endoscopy (ESGE) position statement. Endoscopy. (2020) 52(8):669–86. doi: 10.1055/a-1185-1289
33. Taylor AC, Buttigieg RJ, McDonald IG, Desmond PV. Prospective assessment of the diagnostic and therapeutic impact of small-bowel push enteroscopy. Endoscopy. (2003) 35(11):951–6. doi: 10.1055/s-2003-43476
34. Gerson LB. Small bowel endoscopy: cost-effectiveness of the different approaches. Best Pract Res Clin Gastroenterol. (2012) 26(3):325–35. doi: 10.1016/j.bpg.2012.01.018
35. Richter JM, Kelsey PB, Campbell EJ. Adverse event and complication management in gastrointestinal endoscopy. Am J Gastroenterol. (2016) 111(3):348–52. doi: 10.1038/ajg.2015.423
36. Efthymiou M, Desmond PV, Brown G, La Nauze R, Kaffes A, Chua TJ, et al. SINGLE-01: a randomized, controlled trial comparing the efficacy and depth of insertion of single- and double-balloon enteroscopy by using a novel method to determine insertion depth. Gastrointest Endosc. (2012) 76(5):972–80. doi: 10.1016/j.gie.2012.06.033
37. Lipka S, Rabbanifard R, Kumar A, Brady P. Single versus double balloon enteroscopy for small bowel diagnostics: a systematic review and meta-analysis. J Clin Gastroenterol. (2015) 49(3):177–84. doi: 10.1097/MCG.0000000000000274
38. Koh JTE, Kim Wei L, Francisco CP, Ravi R, Chan W, Khor C, et al. Double balloon enteroscopy versus single balloon enteroscopy: a comparative study. Medicine (Baltimore). (2024) 103(20):e38119. doi: 10.1097/MD.0000000000038119
39. Kawamura T, Yasuda K, Tanaka K, Uno K, Ueda M, Sanada K, et al. Clinical evaluation of a newly developed single-balloon enteroscope. Gastrointest Endosc. (2008) 68(6):1112–6. doi: 10.1016/j.gie.2008.03.1063
40. Tsujikawa T, Saitoh Y, Andoh A, Imaeda H, Hata K, Minematsu H, et al. Novel single-balloon enteroscopy for diagnosis and treatment of the small intestine: preliminary experiences. Endoscopy. (2008) 40(1):11–5. doi: 10.1055/s-2007-966976
41. American Society for Gastrointestinal Endoscopy Standards of Practice Committee, Shergill AK, Lightdale JR, Bruining DH, Acosta RD, Chandrasekhara V, et al. The role of endoscopy in inflammatory bowel disease. Gastrointest Endosc. (2015) 81(5):1101–1121.e1-13. doi: 10.1016/j.gie.2014.10.030
42. Kramer RE, Brumbaugh DE, Soden JS, Capocelli KE, Hoffenberg EJ. First successful antegrade single-balloon enteroscopy in a 3-year-old with occult GI bleeding. Gastrointest Endosc. (2009) 70(3):546–9. doi: 10.1016/j.gie.2009.04.011
43. Lin TK, Erdman SH. Double-balloon enteroscopy: pediatric experience. J Pediatr Gastroenterol Nutr. (2010) 51(4):429–32. doi: 10.1097/MPG.0b013e3181d2979c
44. Shen R, Sun B, Gong B, Zhang S, Cheng S. Double-balloon enteroscopy in the evaluation of small bowel disorders in pediatric patients. Dig Endosc. (2012) 24(2):87–92. doi: 10.1111/j.1443-1661.2011.01175.x
45. ASGE Standards of Practice Committee, Lightdale JR, Acosta R, Shergill AK, Chandrasekhara V, Chathadi K, et al. Modifications in endoscopic practice for pediatric patients. Gastrointest Endosc. (2014) 79(5):699–710. doi: 10.1016/j.gie.2013.08.014
46. Bizzarri B, Borrelli O, de’Angelis N, Ghiselli A, Nervi G, Manfredi M, et al. Management of duodenal-jejunal polyps in children with Peutz-Jeghers syndrome with single-balloon enteroscopy. J Pediatr Gastroenterol Nutr. (2014) 59(1):49–53. doi: 10.1097/MPG.0000000000000351
47. Belsha D, Urs A, Attard T, Thomson M. Effectiveness of double-balloon enteroscopy-facilitated polypectomy in pediatric patients with Peutz-Jeghers syndrome. J Pediatr Gastroenterol Nutr. (2017) 65(5):500–2. doi: 10.1097/MPG.0000000000001576
48. Chen H, Liu Y, Fu L, Lin X, Fan D, Li C. Clinical utility of double-balloon enteroscopy in children: a single-centre experience in South China. J Paediatr Child Health. (2019) 55(2):188–93. doi: 10.1111/jpc.14153
49. Domagk D, Mensink P, Aktas H, Lenz P, Meister T, Luegering A, et al. Single- vs. double-balloon enteroscopy in small-bowel diagnostics: a randomized multicenter trial. Endoscopy. (2011) 43(6):472–6. doi: 10.1055/s-0030-1256247
50. Yamamoto H, Ell C, Binmoeller KF. Double-balloon endoscopy. Endoscopy. (2008) 40(9):779–83. doi: 10.1055/s-2008-1077518
51. ASGE Standards of Practice Committee, Khashab MA, Pasha SF, Muthusamy VR, Acosta RD, Bruining DH, et al. The role of deep enteroscopy in the management of small-bowel disorders. Gastrointest Endosc. (2015) 82(4):600–7. doi: 10.1016/j.gie.2015.06.046
52. Barth BA, Channabasappa N. Single-balloon enteroscopy in children: initial experience at a pediatric center. J Pediatr Gastroenterol Nutr. (2010) 51(5):680–4. doi: 10.1097/MPG.0b013e3181e85b3d
53. ASGE Standards of Practice Committee, Faulx AL, Lightdale JR, Acosta RD, Agrawal D, Bruining DH, et al. Guidelines for privileging, credentialing, and proctoring to perform GI endoscopy. Gastrointest Endosc. (2017) 85(2):273–81. doi: 10.1016/j.gie.2016.10.036
54. Haycock AV, Youd P, Bassett P, Saunders BP, Tekkis P, Thomas-Gibson S. Simulator training improves practical skills in therapeutic GI endoscopy: results from a randomized, blinded, controlled study. Gastrointest Endosc. (2009) 70(5):835–45. doi: 10.1016/j.gie.2009.01.001
55. Singh S, Sedlack RE, Cook DA. Effects of simulation-based training in gastrointestinal endoscopy: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. (2014) 12(10):1611–1623.e4. doi: 10.1016/j.cgh.2014.01.037
56. Grover SC, Garg A, Scaffidi MA, Yu JJ, Plener IS, Yong E, et al. Impact of a simulation training curriculum on technical and nontechnical skills in colonoscopy: a randomized trial. Gastrointest Endosc. (2015) 82(6):1072–9. doi: 10.1016/j.gie.2015.04.008
57. van der Wiel SE, Küttner Magalhães R, Rocha Gonçalves CR, Dinis-Ribeiro M, Bruno MJ, Koch AD. Simulator training in gastrointestinal endoscopy—from basic training to advanced endoscopic procedures. Best Pract Res Clin Gastroenterol. (2016) 30(3):375–87. doi: 10.1016/j.bpg.2016.04.004
58. Sedlack RE. Validation of computer simulation training for esophagogastroduodenoscopy: pilot study. J Gastroenterol Hepatol. (2007) 22(8):1214–9. doi: 10.1111/j.1440-1746.2007.04841.x
59. McConnell RA, Kim S, Ahmad NA, Falk GW, Forde KA, Ginsberg GG, et al. Poor discriminatory function for endoscopic skills on a computer-based simulator. Gastrointest Endosc. (2012) 76(5):993–1002. doi: 10.1016/j.gie.2012.07.024
60. Ende A, Zopf Y, Konturek P, Naegel A, Hahn EG, Matthes K, et al. Strategies for training in diagnostic upper endoscopy: a prospective, randomized trial. Gastrointest Endosc. (2012) 75(2):254–60. doi: 10.1016/j.gie.2011.07.063
61. Mehdizadeh S, Ross A, Gerson L, Leighton J, Chen A, Schembre D, et al. What is the learning curve associated with double-balloon enteroscopy? Technical details and early experience in 6 U.S. tertiary care centers. Gastrointest Endosc. (2006) 64(5):740–50. doi: 10.1016/j.gie.2006.05.022
62. Gross SA, Stark ME. Initial experience with double-balloon enteroscopy at a U.S. center. Gastrointest Endosc. (2008) 67(6):890–7. doi: 10.1016/j.gie.2007.07.047
63. Huang JG, Tanpowpong P. Paediatric gastrointestinal endoscopy in the Asian-Pacific region: recent advances in diagnostic and therapeutic techniques. World J Gastroenterol. (2023) 29(18):2717–32. doi: 10.3748/wjg.v29.i18.2717
64. Schembre DB, Ross AS. Spiral enteroscopy: a new twist on overtube-assisted endoscopy. Gastrointest Endosc. (2009) 69(2):333–6. doi: 10.1016/j.gie.2008.09.011
65. Morgan D, Upchurch B, Draganov P, Binmoeller KF, Haluszka O, Jonnalagadda S, et al. Spiral enteroscopy: prospective U.S. multicenter study in patients with small-bowel disorders. Gastrointest Endosc. (2010) 72(5):992–8. doi: 10.1016/j.gie.2010.07.013
66. Nagula S, Gaidos J, Draganov PV, Bucobo JC, Cho B, Hernandez Y, et al. Retrograde spiral enteroscopy: feasibility, success, and safety in a series of 22 patients. Gastrointest Endosc. (2011) 74(3):699–702. doi: 10.1016/j.gie.2011.05.017
Keywords: pediatric deep enteroscopy, balloon-assisted enteroscopy, small bowel disorders, diagnostics and therapeutics, pediatric gastroenterology, push enteroscopy, single-balloon enteroscopy, double-balloon enteroscopy
Citation: Hoskins BJ (2025) Deep enteroscopy in children: techniques, applications, and future directions. Front. Pediatr. 13:1562075. doi: 10.3389/fped.2025.1562075
Received: 16 January 2025; Accepted: 25 February 2025;
Published: 12 March 2025.
Edited by:
Kenneth Ng, Johns Hopkins University, United StatesReviewed by:
Rajmohan Dharmaraj, University of New Mexico, United StatesCopyright: © 2025 Hoskins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Brett J. Hoskins, Ympob3NraW5AaXUuZWR1