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ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 13 - 2025 | doi: 10.3389/fped.2025.1547958
Gut microbiota dysbiosis in infantile cholestatic hepatopathy
Provisionally accepted- 1 Department of clinical laboratory, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, enshi, China
- 2 Department of Technology, Puluo (Wuhan) Medical Biotechnology Co., Ltd., Wuhan, Hebei Province, China
- 3 Department of Marketing, Wuhan Kindstar Clinical Diagnostic Institute Co., Ltd., Wuhan, China
- 4 Department of Neurology, Wuhan Children’s Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 5 Emergency and Critical Care Medical Center, Wuhan Children’s Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
- 6 Department of clinical laboratory, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Wuhan, China
Background: Cholestatic hepatopathy is common in infants. While many studies link gut microbiota to liver and gallbladder diseases, the relationship between infantile cholestatic hepatopathy (ICH) and gut microbiota remains unclear.We collected stool samples from 19 healthy controls and 33 infants with ICH aged ≤ 3 months, then determined the intestinal microbiota by 16S rDNA sequencing. The differences of microbiota structure and functional between the two groups were analyzed.Results: Alpha-diversity analysis showed that the Chao1 and ACE indexes were significantly higher in the ICH group than control group (p < 0.05). LEfSe analysis showed that 18 bacteria taxa, including Streptococcus, Streptococcaceae, and Staphylococcales, enriched significantly in the ICH group, and 3 bacteria taxa were enriched in the control group. At the genus level, the relative abundance of Streptococcus, Escherichia-Shigella, and Lactobacillus in ICH group was higher than control group (p < 0.05). The Receiver Operating Characteristic (ROC) analysis demonstrated that Streptococcus was highly valuable in distinguishing ICH from s 删除[Adminstrator]:
Keywords: Infantile cholestatic hepatopathy, intestinal microbiota, 16S rDNA, Streptococcus, Biomarker 1
Received: 19 Dec 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Zou, Ni, Zhou, Dan, Chen and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Feng Chen, Emergency and Critical Care Medical Center, Wuhan Children’s Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
Xianyun Li, Department of clinical laboratory, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Wuhan, China
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