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CASE REPORT article
Front. Pediatr.
Sec. Pediatric Oncology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1539220
This article is part of the Research Topic Cancer, Metabolism and Kidney Injury: From Molecular Mechanisms to Therapy View all articles
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Metanephric adenoma (MA) is a rare benign renal tumor, with an incidence of 0.2% to 1%.Approximately 90% of MA cases present with the BRAF V600E mutation. This study reports an 8-year-old male child who presented with abdominal pain for one month. Abdominal ultrasound revealed a cystic necrotic mass measuring 56x45mm in the right kidney. A preliminary diagnosis of Wilms tumor (WT) led to the initiation of preoperative vincristine Sildi: 1585 27 Sildi: 1 28 Sildi: 93 29 Biçimlendirdi: Yazı tipi: Times New Roman, 12 nk therapy. Right nephroureterectomy was performed by pediatric surgery. Histopathological 30 analysis could not differentiate between MA and WT. Immunohistochemical findings were 31 positive for WT1, PANCK (weak focal), INI1 (intact), PAX8, CD56, and CD57. Genetic testing 32 confirmed the presence of the BRAF V600E mutation (1799T>A, 1799_1800TG>AA). The 33 patient was diagnosed with MA and was followed without chemotherapy. In conclusion, MA, 34 which can be mistaken for WT, should be considered in the differential diagnosis of pediatric 35 renal neoplasms. Immunohistochemical evaluation and genetic testing are essential for a 36 definitive diagnosis. 37
Keywords: Metanephric adenoma, Willms tumor, BRAF V600E mutation, Case Report Metanephric Adenoma, BRAF V600E mutation 38
Received: 18 Dec 2024; Accepted: 20 Mar 2025.
Copyright: © 2025 Çalışkan Kamış, Yağcı, Koç and Taş. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Şule Çalışkan Kamış, Adana City Training and Research Hospital, Ministry of Health (Turkey), Adana, Türkiye
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