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CASE REPORT article

Front. Pediatr.
Sec. Pediatric Surgery
Volume 13 - 2025 | doi: 10.3389/fped.2025.1534277
This article is part of the Research Topic Innovative Approaches in Pediatric Surgical Oncology Volume II View all 5 articles

Pleuropulmonary blastoma in a 3-year-old child with persistent fever: A case report

Provisionally accepted
瑞琪 岳 瑞琪 岳 Guixia Ma Guixia Ma Li Mao Li Mao Qian Ni Qian Ni *
  • Lanzhou University Second Hospital, Lanzhou, China

The final, formatted version of the article will be published soon.

    Pleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant mesenchymal tumor, representing the most common malignant lung tumor in children.It is often misdiagnosed or underdiagnosed due to its clinical presentation, which mimics acute respiratory infections. Additionally, imaging manifestations are frequently indistinguishable from congenital respiratory malformations or severe lung infections. The tumor has high rates of recurrence and metastasis and has a poor prognosis. Currently, the internationally recommended treatment for PPB is a combination of surgery, chemotherapy, and radiotherapy. This article discusses the diagnosis and treatment of a 3-year-old girl with PPB combined with severe pneumonia.

    Keywords: Pleuropulmonary blastoma, Pediatric lung tumor, acute respiratory infections, Misdiagnosis, DICER1 mutation

    Received: 25 Nov 2024; Accepted: 29 Jan 2025.

    Copyright: © 2025 岳, Ma, Mao and Ni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qian Ni, Lanzhou University Second Hospital, Lanzhou, China

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