94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Surgery
Volume 13 - 2025 | doi: 10.3389/fped.2025.1526900
Clinical Application of Color Doppler Ultrasound for Assessing Hemodynamic Changes in Pediatric Moyamoya Patientsthe Children with Moyamoya Disease Undergoing Combined Revascularization Surgery
Provisionally accepted
Chenyun Zhou*
Hang Ji
Hongxia FanYue LiLina HanAnqi XiaoXiaoxia ZhuHaogeng SunZhizhi TanYing He
Yi Liu*- West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: To investigate the advantages of color Doppler ultrasound (CDUS) in detecting hemodynamic alterations in children with moyamoya disease (MMD) following combined revascularization surgery. Methods: The common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), and superficial temporal artery (STA) were measured by CDUS. Hemodynamic parameters including arterial diameter, peak systolic velocity (PSV), resistance index (RI), and blood flow volume (FV) were collected at three time points: pre-operation (T1), one week after operation (T2), and three months after operation (T3). Twelve children without intracranial arterial disease were recruited as the control group. Matsushima classification-based on digital subtraction angiography (DSA) was applied at T2. Results: Among the 12 children with MMD, 11 patients with bilateral arterial stenosis and 1 patient with unilateral being affected. Compared to the 24 control hemispheres, the diameter of the ICA was significantly smaller in the 23 MMD hemispheres (p < 0.001) with an increased PSV of CCA and ECA, and a decrease FV of carotid arteries (p < 0.05). In MMD group, CDUS revealed increased diameter and FV, decreased RI of STA at the operative side at T2. The PSV and FV of ECA at the operative side increased from T1 to T3 (p < 0.05). Six cases were allocated to satisfactory compensation group (S Group, Matsushima classification grade A and B) and six cases to dissatisfactory compensation group (DS Group, Matsushima classification grade C). The increase in FV of STA on the operative side was higher in S Group at T2 than DS Group (Spearman rho = -0.693, p = 0.039). Conclusion: As a noninvasive imaging modality, carotid and superficial temporal arteries ultrasound may serve as a valuable adjunct to invasive imaging techniques for children with MMD.
Keywords: pediatric, Moyamoya Disease, Color Doppler ultrasound, Superficial temporal artery, carotid artery, Hemodynamics
Received: 13 Nov 2024; Accepted: 11 Apr 2025.
Copyright: © 2025 Zhou, Ji, Fan, Li, Han, Xiao, Zhu, Sun, Tan, He and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chenyun Zhou, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
Yi Liu, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.