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REVIEW article
Front. Pediatr.
Sec. Pediatric Immunology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1520804
This article is part of the Research Topic Advances in the diagnosis, management and outcomes of Immune-Mediated Skin Diseases in children View all 4 articles
IL -36RN Gene: Key Insights into Its Role in Pediatric Pustular Psoriasis Pathogenesis and Treatment
Provisionally accepted- 1 University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
- 2 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 3 jiangsu province hospital of traditional chinese medicine chongqing hospital, Chongqing, China
- 4 Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
Pediatric pustular psoriasis (PPP) is an autoimmune skin disease that seriously affects the physical and mental health of children. The IL-36RN (Interleukin-36 Receptor Antagonist) gene plays a key role in the pathogenesis of PPP. This review comprehensively elaborates on the research progress of IL-36RN in the context of the pathogenesis and treatment of PPP, covering the basic structure, 2 function, mutation sites and types, and inheritance patterns of the gene and its role in the pathogenesis of PPP. In addition, we discussed the frequency of IL-36RN mutations in patients with different types of PPP and the treatment methods for these patients, aiming to provide a valuable reference for further research and treatment of this disease.
Keywords: IL-36RN, gene mutation, Treatment, pediatric, Pustular psoriasis
Received: 31 Oct 2024; Accepted: 25 Feb 2025.
Copyright: © 2025 Wang, Li, Hou, Wang, Guo and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xurui Wang, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
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