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BRIEF RESEARCH REPORT article

Front. Pediatr.
Sec. Neonatology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1510838

Factors associated with elevated Gentamicin Trough Levels in Neonates: A retrospective Analysis of Dosing and clinical Parameters

Provisionally accepted
Julian Trah Julian Trah 1,2*Philipp Deindl Philipp Deindl 1Alexandra Luister Alexandra Luister 1,3Claudia Langebrake Claudia Langebrake 1Dominique Singer Dominique Singer 1Chinedu Ulrich Ebenebe Chinedu Ulrich Ebenebe 1
  • 1 University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany
  • 2 VAMED Rehaklinik Geesthacht, Geesthacht, Germany
  • 3 University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany

The final, formatted version of the article will be published soon.

    METHODS This single-center retrospective analysis used a multivariate linear regression model to explore the relationship between gentamicin trough concentrations and factors such as creatinine levels, dosage, day of life, sex, CRP levels, and dosing interval in neonates.In 215 neonates, including 68 (31.6%) premature neonates with a postmenstrual age of ≤ 35 weeks, shorter dosing intervals, higher creatinine levels, and increased dosage were linked to higher gentamicin trough levels. Elevated CRP levels corresponded with lower trough levels.CONCLUSION This study highlights the critical role of dosing frequency, kidney function, and inflammatory status in influencing gentamicin trough levels in neonates. However, all gentamicin trough levels were within the 2 µg/mL threshold.

    Keywords: ABBREVIATIONS CRP, C-reactive protein; SD, Standard deviation Neonate, Gentamicin, aminoglycoside, trough levels

    Received: 14 Oct 2024; Accepted: 03 Feb 2025.

    Copyright: © 2025 Trah, Deindl, Luister, Langebrake, Singer and Ebenebe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Julian Trah, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Hamburg, Germany

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.