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REVIEW article
Front. Pediatr.
Sec. Pediatric Hematology and Hematological Malignancies
Volume 13 - 2025 | doi: 10.3389/fped.2025.1509612
This article is part of the Research Topic Infection, Immunity and Microecology in Children View all 3 articles
Microbiota modulation for infectious complications following allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies
Provisionally accepted- Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China
The intervention of microbiota modulation in the treatment of infection complications after allogeneic hematopoietic stem cell transplantation in pediatric patients with hematological malignancies has shown potential benefits. Through the use of probiotics, prebiotics, synbiotics, and fecal microbiota transplantation(FMT), these interventions modulate the gut microbiota and enhance immune function to prevent and treat infections. They have been shown to reduce the incidence of diarrhea and intestinal infections, mitigate the issue of antibiotic resistance, and promote the recovery of gut microbiota. Future research is needed to further assess the safety and efficacy of these interventions and to establish standardized treatment protocols.
Keywords: microbiota modulation, Gut Microbiota, Pediatric hematological malignancies, allogeneic hematopoietic stem cell transplantation, Infection complications
Received: 11 Oct 2024; Accepted: 26 Feb 2025.
Copyright: © 2025 Dai, chen, Zhou, Liu, Jin and GUO. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
mengdi Jin, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China
ZHI GUO, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China
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