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CASE REPORT article

Front. Pediatr.
Sec. Pediatric Surgery
Volume 13 - 2025 | doi: 10.3389/fped.2025.1496553

Case report: Innovative Anesthetic Approaches for Whole Lung Lavage in an Infant with Pulmonary Alveolar Proteinosis

Provisionally accepted
Jiaxiang Chen Jiaxiang Chen Xiaoli Shi Xiaoli Shi Youbing Tu Youbing Tu Yuanzhen Chen Yuanzhen Chen Xueqing Wang Xueqing Wang Jing Shen Jing Shen Liang Xu Liang Xu Ligang Meng Ligang Meng *
  • Department of Anesthesiology, Shenzhen Children's Hospital, Shenzhen, China

The final, formatted version of the article will be published soon.

    Introduction: Pulmonary alveolar proteinosis (PAP) is a rare disease in infancy characterized by the accumulation of lipoprotein material within the alveoli, leading to impaired gas exchange, ventilation-perfusion mismatch, and, in severe cases, respiratory failure that may result in death. Treatment options include medical therapy and whole lung lavage (WLL), typically requiring lung isolation techniques or extracorporeal membrane oxygenation. Previous studies have reported the application of several lung isolation techniques in pediatric WLL. However, the use of a bronchial blocker (BB) in infant WLL has not been previously reported.Case Description: This study reports the anesthesia management of a 12-month-old infant diagnosed with secondary PAP, complicated by severe pneumonia and patent ductus arteriosus. The child presented with respiratory failure requiring WLL. The anesthesia method employed was intravenous general anesthesia, and airway management involved using a BB placed outside the endotracheal tube to facilitate one-lung ventilation (OLV). The procedure successfully maintained blood oxygen levels above 90%, and the WLL was completed without any anesthetic complications.This case demonstrates that using endotracheal intubation combined with extraluminal placement of a BB for lung isolation is a viable and effective approach for performing WLL in infants.

    Keywords: Whole lung lavage, Pulmonary Alveolar Proteinosis, pediatric anesthesia, Bronchial blocker, One-Lung Ventilation

    Received: 14 Sep 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Chen, Shi, Tu, Chen, Wang, Shen, Xu and Meng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ligang Meng, Department of Anesthesiology, Shenzhen Children's Hospital, Shenzhen, China

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