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ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Cardiology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1472431
This article is part of the Research Topic Imaging, diagnosis and interventional treatment of congenital heart disease in children View all 6 articles
Improvement of Pulmonary Edema and Respiratory Status After Transcatheter PDA Closure in the Smallest and Most Premature Infants
Provisionally accepted- Riley Hospital for Children, Indianapolis, United States
We evaluated the effect of transcatheter PDA closure (TCDC) on pulmonary edema by chest x-ray and respiratory status in preterm infants and identified factors contributing to clinical improvement.A retrospective review of TCDC in 68 premature infants from January 2017 to June 2021. Chest x-rays were reviewed to assess pulmonary edema. Multiple clinical characteristics were also evaluated.40% of patients weaned respiratory support. X-ray haziness change was not significantly different between groups (p=0.086), however trended toward significance. 59% had decreased haziness and 16% had a marked decrease. Smaller, younger infants were more likely to wean support and have improved edema.Chest x-ray haziness improved after TCDC, with smaller infants and earlier closure having more improvement. Infants with lung disease had less noticeable improved edema, indicating the difficulty to assess the hemodynamic significance of their PDA prior to closure. Further studies are needed to identify which neonates benefit most from TCDC.
Keywords: interventional pediatric cardiology, transcatheter PDA closure, preterm infants, Respiratory status, patent ductus arteriosus
Received: 29 Jul 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Chmaisse, Swanson, Ross, Cooper, Lorant and Alexy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ahmad Chmaisse, Riley Hospital for Children, Indianapolis, United States
Kaitlin E Swanson, Riley Hospital for Children, Indianapolis, United States
Ryan D Alexy, Riley Hospital for Children, Indianapolis, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.