
95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Cardiology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1438400
The final, formatted version of the article will be published soon.
You have multiple emails registered with Frontiers:
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Vasovagal syncope (VVS) is the most common childhood neurally mediated syncope. This study aims to define the different hemodynamic patterns in pediatric cases of vasovagal syncope and the difference between supine and upright blood pressure (orthostatic blood pressure), and other factors affecting them. Medical records of 88 children with normal laboratory and subclinical tests referred to Mofid Hospital for head-up tilt testing were retrospectively evaluated. Eightyfive children, 31 (36.5%) boys and 54 (63.5%) girls, aged 10.72 ± 3.52 years (median 10; range 4-17), with vasovagal syncope, were enrolled in the study. Age, sex, baseline heart rate, baseline blood pressure, orthostatic blood pressure, provoking factors, symptoms, and frequency were recorded. The test protocol included 10 minutes of supine rest followed by 30 minutes of upright positioning at a 70-degree angle. Subjects were divided into groups according to their differing hemodynamic patterns based on modified VASIS criteria. Our data showed a strong association between the difference in supine and upright blood pressure and positive HUTT results (p = 0.001). In the positive HUTT group, age had a higher probability of vasodepressor pattern in younger patients (p-value=0.014). Also, a significant relationship is seen with the boys (p- § The authors Mohammad Reza Khalilian and Fargol Farahmandi have contributed equally to this work and share first authorship. value=0.014, 0.038), which means that the male gender increases the probability of a positive tilt test.In conclusion, our study indicates that orthostatic blood pressure can predict HUTT in VVS children. Also, our results showed there is a higher chance of having a positive response to HUTT for the younger boys. Further studies in this field are warranted.
Keywords: neurally mediated syncope, Pediatric syncope, Vasovagal, Head-up tilt test, Syncope
Received: 25 May 2024; Accepted: 17 Mar 2025.
Copyright: © 2025 Khalilian, Nasehi, Farahmandi, Farahmandi, Tahouri and Parhizgar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fargol Farahmandi, Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Tehran, Iran
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Research integrity at Frontiers
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.